2015 - 2019年美国与猪耳朵宠物零食相关人群中多重耐药感染的暴发：一项多州调查结果

Outbreak of multidrug-resistant infections in people linked to pig ear pet treats, United States, 2015-2019: results of a multistate investigation.

作者信息

Nichols Megin, Stapleton G Sean, Rotstein David S, Gollarza Lauren, Adams Jennifer, Caidi Hayat, Chen Jessica, Hodges April, Glover Mark, Peloquin Sarah, Payne Lloyd, Norris Anne, DeLancey Siobhan, Donovan Danielle, Dietrich Steve, Glaspie Stevie, McWilliams Karen, Burgess Elizabeth, Holben Beth, Pietrzen Karen, Benko Scott, Feldpausch Emily, Orel Sydney, Neises Daniel, Kline Kelly E, Tobin Bradley, Caron Genevieve, Viveiros Brendalee, Miller Adam, Turner Christina, Holmes-Talbot Kimberly, Mank Laurn, Nishimura Christina, Nguyen Tu Ngoc, Hale Shelby, Francois Watkins Louise K

机构信息

Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.

出版信息

Lancet Reg Health Am. 2024 May 23;34:100769. doi: 10.1016/j.lana.2024.100769. eCollection 2024 Jun.

DOI:10.1016/j.lana.2024.100769

PMID:38817954

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11137515/

Abstract

BACKGROUND

International distribution of contaminated foods can be a source of infections in people and can contribute to the spread of antimicrobial-resistant bacteria across countries. We report an investigation led by the United States Centers for Disease Control and Prevention, the Food and Drug Administration (FDA), and state governmental officials into a multistate outbreak of salmonellosis linked to pig ear pet treats.

METHODS

Pig ear treats and companion dogs were tested for by state officials and the FDA. Products were traced back to the country of origin when possible. Cases were defined as outbreak illnesses in people associated with one of seven serotypes genetically related to samples from pig ear pet treats, with isolation dates from June 2015 to September 2019. Whole genome sequencing (WGS) of isolates was used to predict antimicrobial resistance.

FINDINGS

The outbreak included 154 human cases in 34 states. Of these, 107 of 122 (88%) patients reported dog contact, and 65 of 97 (67%) reported contact with pig ear pet treats. was isolated from 137 pig ear treats, including some imported from Argentina, Brazil, and Colombia, and from four dogs. WGS predicted 77% (105/137) of human and 43% (58/135) of pig ear treat isolates were resistant to ≥3 antimicrobial classes.

INTERPRETATION

This was the first documented United States multistate outbreak of infections linked to pig ear pet treats. This multidrug-resistant outbreak highlights the interconnectedness of human health and companion animal ownership and the need for zoonotic pathogen surveillance to prevent human illness resulting from internationally transported pet food products.

FUNDING

Animal Feed Regulatory Program Standards award. Animal and product testing conducted by FDA Vet-LIRN was funded by Vet-LIRN infrastructure grants (PAR-22-063).

摘要

背景

受污染食品的国际流通可能成为人类感染的来源，并可能促使耐药菌在各国传播。我们报告了一项由美国疾病控制与预防中心、食品药品监督管理局（FDA）以及州政府官员牵头的调查，该调查针对一起与猪耳朵宠物零食相关的多州沙门氏菌病暴发事件。

方法

州政府官员和FDA对猪耳朵零食及宠物狗进行了检测。产品尽可能追溯至原产国。病例定义为与七种血清型之一相关的人类暴发疾病，这些血清型在基因上与猪耳朵宠物零食样本相关，隔离日期为2015年6月至2019年9月。分离株的全基因组测序（WGS）用于预测抗菌药物耐药性。

研究结果

此次暴发涉及34个州的154例人类病例。其中，122例患者中的107例（88%）报告与狗有接触，97例中的65例（67%）报告与猪耳朵宠物零食有接触。从137份猪耳朵零食中分离出了[病原体名称未给出]，包括一些从阿根廷、巴西和哥伦比亚进口的产品，以及从四只狗身上分离出的[病原体名称未给出]。WGS预测，77%（105/137）的人类分离株和43%（58/135）的猪耳朵零食分离株对≥3类抗菌药物耐药。