cGAS-STING 信号通路在病毒感染、炎症和自身免疫性疾病中的作用。
The role of the cGAS-STING signaling pathway in viral infections, inflammatory and autoimmune diseases.
机构信息
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macao, 999078, China.
Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, 14183, Sweden.
出版信息
Acta Pharmacol Sin. 2024 Oct;45(10):1997-2010. doi: 10.1038/s41401-023-01185-5. Epub 2024 Jun 1.
Pattern recognition receptors are an essential part of the immune system, which detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) and help shape both innate and adaptive immune responses. When dsDNA is present, cyclic GMP-AMP Synthase (cGAS) produces a second messenger called cyclic GMP-AMP (cGAMP), which then triggers an adaptor protein called STING, and eventually activates the expression of type I interferon (IFN) and pro-inflammatory cytokines in immune cells. The cGAS-STING signaling pathway has been receiving a lot of attention lately as a key immune-surveillance mediator. In this review, we summarize the present circumstances of the cGAS-STING signaling pathway in viral infections and inflammatory diseases, as well as autoimmune diseases. Modulation of the cGAS-STING signaling pathway provides potential strategies for treating viral infections, inflammatory diseases, and autoimmune diseases.
模式识别受体是免疫系统的重要组成部分，可识别病原体相关分子模式 (PAMPs) 和损伤相关分子模式 (DAMPs)，并有助于形成先天和适应性免疫反应。当双链 DNA 存在时，环鸟苷酸-腺苷酸合成酶 (cGAS) 会产生一种称为环鸟苷酸-腺苷酸 (cGAMP) 的第二信使，然后触发一种称为 STING 的衔接蛋白，最终激活免疫细胞中 I 型干扰素 (IFN) 和促炎细胞因子的表达。cGAS-STING 信号通路最近作为一种关键的免疫监测介质受到了广泛关注。在这篇综述中，我们总结了 cGAS-STING 信号通路在病毒感染、炎症性疾病和自身免疫性疾病中的现状。cGAS-STING 信号通路的调节为治疗病毒感染、炎症性疾病和自身免疫性疾病提供了潜在策略。
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