miR-26a和miR-26b微小RNA是妊娠期糖尿病的有效预后标志物吗？
Are miR-26a and miR-26b microRNAs potent prognostic markers of gestational diabetes?
作者信息
Ghaneialvar Hori, Mohseni Mahdieh Mehrab, Kenarkoohi Azra, Kakaee Saeed
机构信息
Biotechnology and Medicinal Plants Research Center Ilam University of Medical Sciences Ilam Iran.
Student Research Committee Ilam University of Medical Sciences Ilam Iran.
出版信息
Health Sci Rep. 2024 Jun 2;7(6):e2152. doi: 10.1002/hsr2.2152. eCollection 2024 Jun.
BACKGROUND
Gestational diabetes mellitus is a common public health problem, accompanied by complications for the mother and fetus. So, introducing new biomarkers to identify early diabetes is essential. As serum miRNAs are potentially appropriate markers, we investigated miR-26a and miR-26b expression levels in pregnant women with and without gestational diabetes.
METHOD
Demographic and clinical characteristics of 40 gestational diabetic patients and 40 healthy controls were assessed. The expression level of miR-26a and miR-26b microRNAs was measured by real-time PCR. Statistical analysis was done with GraphPad Prism software (version 8.4.3).
RESULT
The findings of this study showed that the expression level of miR-26a and miR-26b increased in women with gestational diabetes compared with healthy pregnant women, but the increase in expression was only significant for miR-26a ( < 0.05).
CONCLUSION
According to the statistical and ROC curves, we suggest miR-26a as a potential biomarker for the early diagnosis of gestational diabetes mellitus.
背景
妊娠期糖尿病是一个常见的公共卫生问题，会伴有母婴并发症。因此，引入新的生物标志物以早期识别糖尿病至关重要。由于血清微小RNA可能是合适的标志物，我们研究了患有和未患有妊娠期糖尿病的孕妇中miR-26a和miR-26b的表达水平。
方法
评估了40例妊娠期糖尿病患者和40例健康对照者的人口统计学和临床特征。通过实时聚合酶链反应测量miR-26a和miR-26b微小RNA的表达水平。使用GraphPad Prism软件（8.4.3版）进行统计分析。
结果
本研究结果表明，与健康孕妇相比，妊娠期糖尿病女性中miR-26a和miR-26b的表达水平升高，但仅miR-26a的表达升高具有统计学意义（<0.05）。
结论
根据统计结果和ROC曲线，我们建议将miR-26a作为早期诊断妊娠期糖尿病的潜在生物标志物。
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