Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Microbiology, Faculty of Veterinary and Agriculture, Islamic Azad University, Shabestar branch, Shabestar, Iran.
Biomed Pharmacother. 2024 Aug;177:116951. doi: 10.1016/j.biopha.2024.116951. Epub 2024 Jun 19.
The emerging strategy of biomimetic nanoparticles (NPs) via cellular membrane camouflage holds great promise in cancer therapy. This scholarly review explores the utilization of cellular membranes derived from diverse cellular entities; blood cells, immune cells, cancer cells, stem cells, and bacterial cells as examples of NP coatings. The camouflaging strategy endows NPs with nuanced tumor-targeting abilities such as self-recognition, homotypic targeting, and long-lasting circulation, thus also improving tumor therapy efficacy overall. The comprehensive examination encompasses a variety of cell membrane camouflaged NPs (CMCNPs), elucidating their underlying targeted therapy mechanisms and delineating diverse strategies for anti-cancer applications. Furthermore, the review systematically presents the synthesis of source materials and methodologies employed in order to construct and characterize these CMCNPs, with a specific emphasis on their use in cancer treatment.
仿生纳米粒子(NPs)通过细胞膜伪装的新兴策略在癌症治疗中具有广阔的前景。本学术综述探讨了利用源自不同细胞实体的细胞膜,如血细胞、免疫细胞、癌细胞、干细胞和细菌细胞作为 NP 涂层的例子。伪装策略赋予 NPs 细微的肿瘤靶向能力,如自我识别、同型靶向和持久循环,从而整体提高肿瘤治疗效果。全面检查涵盖了各种细胞膜伪装纳米粒子(CMCNPs),阐明了它们的潜在靶向治疗机制,并描述了用于抗癌应用的各种策略。此外,本综述系统地介绍了构建和表征这些 CMCNPs 所采用的源材料和方法学,特别强调了它们在癌症治疗中的应用。