结核分枝杆菌休眠期的基因调控机制
Gene Regulatory Mechanism of Mycobacterium Tuberculosis during Dormancy.
作者信息
Liu Yiduo, Li Han, Dai Dejia, He Jiakang, Liang Zhengmin
机构信息
College of Animal Science and Technology, Guangxi University, No. 100 University West Road, Nanning 530004, China.
College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
出版信息
Curr Issues Mol Biol. 2024 Jun 11;46(6):5825-5844. doi: 10.3390/cimb46060348.
Tuberculosis (TB), caused by (Mtb) complex, is a zoonotic disease that remains one of the leading causes of death worldwide. Latent tuberculosis infection reactivation is a challenging obstacle to eradicating TB globally. Understanding the gene regulatory network of Mtb during dormancy is important. This review discusses up-to-date information about TB gene regulatory networks during dormancy, focusing on the regulation of lipid and energy metabolism, dormancy survival regulator (DosR), White B-like (Wbl) family, Toxin-Antitoxin (TA) systems, sigma factors, and MprAB. We outline the progress in vaccine and drug development associated with Mtb dormancy.
由结核分枝杆菌复合群（Mtb）引起的结核病是一种人畜共患病，仍然是全球主要死因之一。潜伏性结核感染的重新激活是全球根除结核病的一个具有挑战性的障碍。了解结核分枝杆菌在休眠期间的基因调控网络很重要。本综述讨论了关于结核休眠期间基因调控网络的最新信息，重点关注脂质和能量代谢的调控、休眠存活调节因子（DosR）、类白B（Wbl）家族、毒素-抗毒素（TA）系统、σ因子和MprAB。我们概述了与结核分枝杆菌休眠相关的疫苗和药物开发进展。
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