胰岛素样生长因子结合蛋白-7的基线水平及纵向变化与新发心力衰竭风险的关联：来自预防肾脏和血管终末期疾病（PREVEND）研究的数据

Association of baseline and longitudinal changes in insulin-like growth factor-binding protein-7 with the risk of incident heart failure: Data from the PREVEND study.

作者信息

Abou Kamar Sabrina, Bracun Valentina, El-Qendouci Maissa, Bomer Nils, Bakker Stephan J L, Gansevoort Ron T, Boersma Eric, Kardys Isabella, de Boer Rudolf A, Suthahar Navin

机构信息

Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC, Rotterdam, The Netherlands.

Department of Cardiology, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.

出版信息

Eur J Heart Fail. 2024 Jul 17. doi: 10.1002/ejhf.3328.

DOI:10.1002/ejhf.3328

PMID:39015086

Abstract

AIM

Senescence is a major risk factor for heart failure (HF), and insulin-like growth factor-binding protein-7 (IGFBP7) has been identified as an important senescence-inducing factor. The aim of this study was to examine the value of baseline and repeat IGFBP7 measurements in predicting future HF among community-dwelling Dutch adults from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study.

METHODS AND RESULTS

Individuals without prevalent HF who attended PREVEND visits 2 and 4 median of 5.1 years apart (25th-75th percentile, 4.9-5.2) with measurements of IGFBP7 were included. We used Cox proportional hazards models to investigate the association between IGFBP7 and HF incidence. A total of 6125 participants attending visit 2 (mean ± standard deviation [SD] age 53.1 ± 12.2 years; 3151 [51.4%] men) were followed for a median of 8.4 (7.8-8.9) years, and 194 participants (3.2%) developed incident HF. Median baseline IGFBP7 concentration was 87.0 (75.1-97.3) ng/ml, and baseline IGFBP7 levels were significantly associated with risk for incident HF (HF risk factors adjusted hazard ratio [HR] per 1 SD change in log-transformed IGFBP7: 1.22, 95% confidence interval [CI] 1.03-1.46). Baseline IGFBP7 was also significantly associated with incident HF in individuals with N-terminal pro-B-type natriuretic peptide <125 ng/L. Among 3879 participants attending both visits 2 and 4 (mean ± SD age 57.5 ± 11.3 years; 1952 [50.3%] men), 93 individuals developed HF (after visit 4) during a median follow-up of 3.2 (2.8-3.9) years. Median increase in IGFBP7 concentration between visits was 0.68 (-7.09 to 8.36) ng/ml, and changes in IGFBP7 levels were significantly associated with risk for incident HF (HF risk factors adjusted HR per 1 SD change in log-transformed IGFBP7: 1.68, 95% CI 1.19-2.36).

CONCLUSIONS

Both baseline as well as repeat IGFBP7 measurements provide information about the risk of developing HF.

摘要

目的

衰老为心力衰竭（HF）的主要危险因素，胰岛素样生长因子结合蛋白7（IGFBP7）已被确定为一种重要的衰老诱导因子。本研究旨在通过预防肾脏和血管终末期疾病（PREVEND）研究，探讨荷兰社区成年居民中，基线及重复检测IGFBP7水平在预测未来发生HF中的价值。

方法与结果

纳入PREVEND研究中无HF病史、分别于第2次和第4次随访（间隔时间中位数为5.1年，四分位数间距为4.9 - 5.2年）时检测过IGFBP7的个体。我们使用Cox比例风险模型研究IGFBP7与HF发病率之间的关联。共有6125名参与者接受了第2次随访（平均年龄±标准差[SD]为53.1±12.2岁；3151名[51.4%]为男性），随访中位数为8.4（7.8 - 8.9）年，其中194名参与者（3.2%）发生了HF。基线IGFBP7浓度中位数为87.0（75.1 - 97.3）ng/ml，基线IGFBP7水平与HF发病风险显著相关（校正HF风险因素后，log转换后的IGFBP7每变化1个标准差的风险比[HR]：1.22，95%置信区间[CI]为1.03 - 1.46）。在N末端B型利钠肽原<125 ng/L的个体中，基线IGFBP7也与HF发病显著相关。在3879名同时接受第2次和第4次随访的参与者中（平均年龄±SD为57.5±11.3岁；1952名[50.3%]为男性），93名个体在随访中位数3.2（2.8 - 3.9）年期间（第4次随访后）发生了HF。两次随访间IGFBP7浓度增加的中位数为0.68（-7.09至8.36）ng/ml，IGFBP7水平变化与HF发病风险显著相关（校正HF风险因素后，log转换后的IGFBP7每变化1个标准差的HR：1.68，95%CI为1.19 - 2.36）。