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2020-2022 年 COVID-19 大流行期间丹麦、芬兰、挪威和瑞典的特定原因超额死亡率:一项使用全国人口数据的研究。

Cause-specific excess mortality in Denmark, Finland, Norway, and Sweden during the COVID-19 pandemic 2020-2022: a study using nationwide population data.

机构信息

Epidemiology, Population Studies and Infrastructures (EPI@LUND), Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.

General Practice Research Unit (AFE) and Department of General Practice, Institute of Health and Society, University of Oslo, Oslo, Norway.

出版信息

Eur J Epidemiol. 2024 Sep;39(9):1037-1050. doi: 10.1007/s10654-024-01154-0. Epub 2024 Sep 16.

Abstract

While there is substantial evidence on excess mortality in the first two years of the COVID-19 pandemic, no study has conducted a cause-specific analysis of excess mortality for the whole period 2020-2022 across multiple countries. We examined cause-specific excess mortality during 2020-2022 in Denmark, Finland, Norway, and Sweden-four countries with similar demographics and welfare provisions, which implemented different pandemic response policies. To this end, we utilized nationwide register-based information on annual cause-specific deaths stratified by age and sex, and applied linear regression models to predict mortality in 2020-2022 based on the reference period 2010-2019. Excess deaths were obtained by contrasting actual and expected deaths. Additional analyses employed standardization to a common population, as well as population adjustments to account for previous deaths. Our results showed that, besides deaths due to COVID-19 (a total of 32,491 during 2020-2022), all countries experienced excess deaths due to cardiovascular diseases (in total 11,610 excess deaths), and under-mortality due to respiratory diseases other than COVID-19 (in total 9878) and dementia (in total 8721). The excess mortality due to cardiovascular diseases was particularly pronounced in Finland and Norway in 2022, and the under-mortality due to dementia was particularly pronounced in Sweden in 2021-2022. In conclusion, while COVID-19 deaths emerge as the most apparent consequence of the pandemic, our findings suggest that mortality has also been influenced by substitutions between different causes of death and over time, as well as indirect consequences of COVID-19 infection and pandemic responses-albeit to different extents in the different countries.

摘要

尽管有大量证据表明 COVID-19 大流行的头两年存在超额死亡,但没有一项研究对 2020-2022 年期间多个国家的全因超额死亡率进行过特定原因的分析。我们研究了丹麦、芬兰、挪威和瑞典这四个人口统计学和福利措施相似、但实施了不同大流行应对政策的国家在 2020-2022 年期间特定原因的超额死亡率。为此,我们利用了全国范围内按年龄和性别分层的年度特定原因死亡的登记处信息,并应用线性回归模型根据参考期 2010-2019 预测 2020-2022 年的死亡率。超额死亡是通过实际死亡人数与预期死亡人数的对比得出的。额外的分析采用了标准化到共同人口以及人口调整以考虑先前的死亡人数。我们的研究结果表明,除了 COVID-19 死亡(2020-2022 年期间总计 32491 人)外,所有国家还经历了心血管疾病的超额死亡(总计 11610 人超额死亡),以及 COVID-19 以外的呼吸道疾病(总计 9878 人)和痴呆症(总计 8721 人)的死亡人数不足。2022 年芬兰和挪威的心血管疾病超额死亡率尤其明显,而 2021-2022 年瑞典的痴呆症超额死亡率尤其明显。总之,虽然 COVID-19 死亡人数是大流行最明显的后果,但我们的研究结果表明,死亡率也受到不同死亡原因之间的替代以及随时间推移的影响,以及 COVID-19 感染和大流行应对的间接后果的影响——尽管在不同国家的程度不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/610b/11470911/8f2eba980d68/10654_2024_1154_Fig1_HTML.jpg

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