血管生成素-4 的表达及其在肿瘤发生中的潜在机制：当前的研究进展和展望。

Angiopoietin-4 expression and potential mechanisms in carcinogenesis: Current achievements and perspectives.

机构信息

Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.

The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

出版信息

Clin Exp Med. 2024 Sep 19;24(1):224. doi: 10.1007/s10238-024-01449-2.

DOI:10.1007/s10238-024-01449-2

PMID:39294405

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11410924/

Abstract

As one of the factors regulating tumour angiogenesis, angiopoietin-4 (ANGPT4), which plays an important role in promoting tumour proliferation, survival, expansion and angiogenesis, is highly expressed in some tumours, such as lung adenocarcinoma, glioblastoma and ovarian cancer. This may be related to the fact that ANGPT4 affects the blood vessels and lymphatic system of the tumour. Specifically, ANGPT4 could play an effective role in promoting cancer by affecting the tyrosine kinase receptor TIE2, ERK1/2 and PI3K/AKT signalling pathways. Therefore, ANGPT4 may be an important biomarker for the occurrence and development of cancer and poor prognosis. In addition, the inhibition of ANGPT4 may be a useful cancer treatment. This paper reviews the latest preclinical research on ANGPT4, emphasizes its role in tumourigenesis and broadens our understanding of the carcinogenic function of ANGPT4 and the development of ANGPT4 inhibitors. This is the latest version of the revised version of the previous article.

摘要

作为调节肿瘤血管生成的因素之一，血管生成素 4（ANGPT4）在促进肿瘤增殖、存活、扩张和血管生成中发挥重要作用，在一些肿瘤中高表达，如肺腺癌、胶质母细胞瘤和卵巢癌。这可能与 ANGPT4 影响肿瘤的血管和淋巴管系统有关。具体来说，ANGPT4 可能通过影响酪氨酸激酶受体 TIE2、ERK1/2 和 PI3K/AKT 信号通路，在促进癌症方面发挥有效作用。因此，ANGPT4 可能是癌症发生发展和预后不良的一个重要生物标志物。此外，抑制 ANGPT4 可能是一种有用的癌症治疗方法。本文综述了 ANGPT4 的最新临床前研究，强调了其在肿瘤发生中的作用，拓宽了我们对 ANGPT4 的致癌功能和 ANGPT4 抑制剂开发的认识。这是对之前文章的最新修订版本。