da Silva Rosileide Zeferino, de Assis Costa Francisco, de Oliveira-Filho Alfredo Dias, Neves Sabrina Joany Felizardo
Department of Pharmacy, Federal University of Alagoas, Maceió, AL, Brazil.
Department of Cardiology, Federal University of Alagoas, Maceió, AL, Brazil.
Explor Res Clin Soc Pharm. 2024 Sep 5;16:100502. doi: 10.1016/j.rcsop.2024.100502. eCollection 2024 Dec.
To validate the General Medication Adherence Scale (GMAS) in Brazilian Portuguese for hypertensive patients.
The GMAS-English was translated into Brazilian Portuguese and adapted for cultural appropriateness by a translation process and expert panel. A cross-sectional study was conducted in northeast Brazilian cardiology divisions of public and private hospitals, interviewing hypertensive patients. Reliability was assessed using Cronbach's alpha, intraclass correlation, and Pearson's correlation. Convergent validity was tested against the BMQ using chi-square. Criterion validity was assessed by comparing GMAS with blood pressure control using chi-square.
The GMAS was translated and adapted according to standard procedures. In a validation study with 167 hypertensive patients, Cronbach's alpha was 0.79, and Pearson's correlation showed significant test-retest reliability ( < 0.001). Convergent validity with BMQ was significant (p < 0.001), with 89.4 % sensitivity for behaviors considered adherent (High adherence and good adherence), but between the strata that measure low adherence (Partial adherence, low adherence and very low adherence), the specificity rate was 50 %. Criterion validity between GMAS and blood pressure control was not observed.
The Brazilian Portuguese version of the GMAS exhibited good consistency and reproducibility, modest agreement with BMQ scale and did not demonstrate acceptable criterion validity for hypertensive patients.
验证巴西葡萄牙语版通用药物依从性量表(GMAS)在高血压患者中的有效性。
将英文版GMAS翻译成巴西葡萄牙语,并通过翻译过程和专家小组进行文化适应性调整。在巴西东北部公立和私立医院的心脏病科开展了一项横断面研究,对高血压患者进行访谈。使用克朗巴哈系数、组内相关系数和皮尔逊相关系数评估信度。使用卡方检验对照BMQ检验聚合效度。通过卡方检验比较GMAS与血压控制情况来评估效标效度。
GMAS已按照标准程序进行翻译和调整。在一项针对167名高血压患者的验证研究中,克朗巴哈系数为0.79,皮尔逊相关系数显示出显著的重测信度(<0.001)。与BMQ的聚合效度显著(p<0.001),对于被视为依从的行为(高依从性和良好依从性),敏感性为89.4%,但在测量低依从性的层次(部分依从性、低依从性和极低依从性)之间,特异度为50%。未观察到GMAS与血压控制之间的效标效度。
巴西葡萄牙语版GMAS表现出良好的一致性和可重复性,与BMQ量表的一致性一般,且未显示出对高血压患者可接受的效标效度。