骨髓增生异常肿瘤/综合征诊断与分类的当代方法——国际骨髓增生异常肿瘤/综合征联盟（MDS [icMDS]）的建议

Contemporary Approach to the Diagnosis and Classification of Myelodysplastic Neoplasms/Syndromes-Recommendations From the International Consortium for Myelodysplastic Neoplasms/Syndromes (MDS [icMDS]).

作者信息

Aakash Fnu, Gisriel Savanah D, Zeidan Amer M, Bennett John M, Bejar Rafael, Bewersdorf Jan Philipp, Borate Uma M, Boultwood Jacqueline, Brunner Andrew M, Buckstein Rena, Carraway Hetty E, Churpek Jane E, Daver Naval G, DeZern Amy E, Efficace Fabio, Fenaux Pierre, Figueroa Maria E, Garcia-Manero Guillermo, Gore Steven D, Greenberg Peter L, Griffiths Elizabeth A, Halene Stephanie, Hourigan Christopher S, Kim Tae Kon, Kim Nina, Komrokji Rami S, Kutchroo Vijay K, List Alan F, Little Richard F, Majeti Ravindra, Nazha Aziz, Nimer Stephen D, Odenike Olatoyosi, Padron Eric, Patnaik Mrinal M, Platzbecker Uwe, Della Porta Matteo G, Roboz Gail J, Sallman David A, Santini Valeria, Sanz Guillermo, Savona Michael R, Sekeres Mikkael A, Stahl Maximilian, Starczynowski Daniel T, Steensma David P, Taylor Justin, Abdel-Wahab Omar, Wei Andrew H, Xie Zhuoer, Xu Mina L, Hasserjian Robert P, Loghavi Sanam

机构信息

Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Pathology, University of Texas Medical Branch, Galveston, Texas.

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin.

出版信息

Mod Pathol. 2024 Dec;37(12):100615. doi: 10.1016/j.modpat.2024.100615. Epub 2024 Sep 23.

DOI:10.1016/j.modpat.2024.100615

PMID:39322118

Abstract

Myelodysplastic neoplasms/syndromes (MDS) are a heterogeneous group of biologically distinct entities characterized by variable degrees of ineffective hematopoiesis. Recently, 2 classification systems (the 5th edition of the World Health Organization Classification of Haematolymphoid tTumours and the International Consensus Classification) further subcharacterized MDS into morphologically and genetically defined groups. Accurate diagnosis and subclassification of MDS require a multistep systemic approach. The International Consortium for MDS (icMDS) summarizes a contemporary, practical, and multimodal approach to MDS diagnosis and classification.

摘要

骨髓增生异常肿瘤/综合征（MDS）是一组生物学上不同的异质性实体，其特征为不同程度的无效造血。最近，两种分类系统（世界卫生组织血液淋巴肿瘤分类第5版和国际共识分类）进一步将MDS细分为形态学和遗传学定义的组。MDS的准确诊断和亚分类需要多步骤的系统方法。国际MDS联盟（icMDS）总结了一种当代、实用且多模式的MDS诊断和分类方法。