衰老生物标志物 CKAP4 和 PTX3 可对严重肾脏疾病患者进行分层。
Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients.
机构信息
Personalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UK.
School of Health and Life Sciences, Teesside University, Campus Heart, Middlesbrough TS1 3BX, UK.
出版信息
Cells. 2024 Sep 26;13(19):1613. doi: 10.3390/cells13191613.
INTRODUCTION
Cellular senescence is the irreversible growth arrest subsequent to oncogenic mutations, DNA damage, or metabolic insult. Senescence is associated with ageing and chronic age associated diseases such as cardiovascular disease and diabetes. The involvement of cellular senescence in acute kidney injury (AKI) and chronic kidney disease (CKD) is not fully understood. However, recent studies suggest that such patients have a higher-than-normal level of cellular senescence and accelerated ageing.
METHODS
This study aimed to discover key biomarkers of senescence in AKI and CKD patients compared to other chronic ageing diseases in controls using OLINK proteomics.
RESULTS
We show that senescence proteins CKAP4 (-value < 0.0001) and PTX3 (-value < 0.0001) are upregulated in AKI and CKD patients compared with controls with chronic diseases, suggesting the proteins may play a role in overall kidney disease development.
CONCLUSIONS
CKAP4 was found to be differentially expressed in both AKI and CKD when compared to UHCs; hence, this biomarker could be a prognostic senescence biomarker of both AKI and CKD.
简介
细胞衰老指的是在致癌突变、DNA 损伤或代谢损伤后不可逆的生长停滞。衰老与年龄相关疾病如心血管疾病和糖尿病有关。细胞衰老在急性肾损伤（AKI）和慢性肾脏病（CKD）中的作用尚未完全清楚。然而，最近的研究表明，此类患者的细胞衰老水平高于正常水平，且衰老速度加快。
方法
本研究旨在使用 OLINK 蛋白质组学技术，与对照组中的其他慢性衰老疾病相比，在 AKI 和 CKD 患者中发现衰老相关的生物标志物。
结果
我们发现，与患有慢性疾病的对照组相比，AKI 和 CKD 患者的衰老蛋白 CKAP4（-值<0.0001）和 PTX3（-值<0.0001）上调，这表明这些蛋白可能在整体肾脏疾病的发展中发挥作用。
结论
与 UHC 相比，CKAP4 在 AKI 和 CKD 中均有差异表达；因此，该生物标志物可能是 AKI 和 CKD 的预后性衰老生物标志物。
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