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神经接口:连接大脑与医疗保健之外的世界。

Neural interfaces: Bridging the brain to the world beyond healthcare.

作者信息

Xu Shumao, Liu Yang, Lee Hyunjin, Li Weidong

机构信息

Department of Biomedical Engineering The Pennsylvania State University Pennsylvania USA.

Brain Health and Brain Technology Center at Global Institute of Future Technology Shanghai Jiao Tong University Shanghai China.

出版信息

Exploration (Beijing). 2024 Mar 14;4(5):20230146. doi: 10.1002/EXP.20230146. eCollection 2024 Oct.

Abstract

Neural interfaces, emerging at the intersection of neurotechnology and urban planning, promise to transform how we interact with our surroundings and communicate. By recording and decoding neural signals, these interfaces facilitate direct connections between the brain and external devices, enabling seamless information exchange and shared experiences. Nevertheless, their development is challenged by complexities in materials science, electrochemistry, and algorithmic design. Electrophysiological crosstalk and the mismatch between electrode rigidity and tissue flexibility further complicate signal fidelity and biocompatibility. Recent closed-loop brain-computer interfaces, while promising for mood regulation and cognitive enhancement, are limited by decoding accuracy and the adaptability of user interfaces. This perspective outlines these challenges and discusses the progress in neural interfaces, contrasting non-invasive and invasive approaches, and explores the dynamics between stimulation and direct interfacing. Emphasis is placed on applications beyond healthcare, highlighting the need for implantable interfaces with high-resolution recording and stimulation capabilities.

摘要

神经接口出现在神经技术与城市规划的交叉点上,有望改变我们与周围环境互动和交流的方式。通过记录和解码神经信号,这些接口促进了大脑与外部设备之间的直接连接,实现了无缝的信息交换和共享体验。然而,它们的发展受到材料科学、电化学和算法设计等方面复杂性的挑战。电生理串扰以及电极刚性与组织柔韧性之间的不匹配,进一步使信号保真度和生物相容性变得复杂。最近的闭环脑机接口虽然在情绪调节和认知增强方面很有前景,但受到解码准确性和用户界面适应性的限制。这篇综述概述了这些挑战,讨论了神经接口的进展,对比了非侵入性和侵入性方法,并探讨了刺激与直接接口之间的动态关系。重点放在医疗保健以外的应用上,强调了对具有高分辨率记录和刺激能力的可植入接口的需求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b2e/11491314/8f5aa29a002f/EXP2-4-20230146-g008.jpg

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