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了解新型冠状病毒感染后的自身免疫反应以及长期新冠的发病机制。

Understanding autoimmune response after SARS-CoV-2 infection and the pathogenesis/mechanisms of long COVID.

作者信息

Guo Ming, Shang Shunlai, Li Mengfei, Cai Guangyan, Li Ping, Chen Xiangmei, Li Qinggang

机构信息

Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases Research, Beijing 100853, China.

Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.

出版信息

Med Rev (2021). 2024 May 27;4(5):367-383. doi: 10.1515/mr-2024-0013. eCollection 2024 Oct.

Abstract

COVID-19 posed a major challenge to the healthcare system and resources worldwide. The popularization of vaccines and the adoption of numerous prevention and control measures enabled the gradual end of the COVID-19 pandemic. However, successive occurrence of autoimmune diseases in patients with COVID-19 cannot be overlooked. Long COVID has been the major focus of research due to the long duration of different symptoms and the variety of systems involved. Autoimmunity may play a crucial role in the pathogenesis of long COVID. Here, we reviewed several autoimmune disorders occurring after COVID-19 infection and the pathogenesis of long COVID.

摘要

新冠病毒肺炎给全球医疗系统和资源带来了重大挑战。疫苗的普及以及众多防控措施的实施使得新冠病毒肺炎大流行逐渐结束。然而,新冠病毒肺炎患者中自身免疫性疾病的相继出现不容忽视。由于不同症状持续时间长且涉及多种系统,“长新冠”一直是研究的主要焦点。自身免疫可能在“长新冠”的发病机制中起关键作用。在此,我们综述了新冠病毒感染后出现的几种自身免疫性疾病以及“长新冠”的发病机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1894/11495526/23fcaeefb785/j_mr-2024-0013_fig_001.jpg

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