与p53网络相关的长链非编码RNA在乳腺癌进展中的作用。
Roles of lncRNAs related to the p53 network in breast cancer progression.
作者信息
Song Jiarui, Cui Qiuxia, Gao Jidong
机构信息
Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
出版信息
Front Oncol. 2024 Oct 16;14:1453807. doi: 10.3389/fonc.2024.1453807. eCollection 2024.
The p53 is a crucial tumor suppressor and transcription factor that participates in apoptosis and senescence. It can be activated upon DNA damage to regulate the expression of a series of genes. Previous studies have demonstrated that some specific lncRNAs are part of the TP53 regulatory network. To enhance our understanding of the relationship between lncRNAs and P53 in cancers, we review the localization, structure, and function of some lncRNAs that are related to the mechanisms of the p53 pathway or serve as p53 transcriptional targets.
p53是一种关键的肿瘤抑制因子和转录因子，参与细胞凋亡和衰老过程。它可在DNA损伤时被激活，以调控一系列基因的表达。先前的研究表明，一些特定的长链非编码RNA（lncRNAs）是TP53调控网络的一部分。为了加深我们对lncRNAs与癌症中P53之间关系的理解，我们综述了一些与p53通路机制相关或作为p53转录靶点的lncRNAs的定位、结构和功能。
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