RH5抗原格局塑造疫苗和抗体的研发。
RH5 antigenic landscape shapes vaccine and antibody development.
作者信息
Patel Palak N, Tolia Niraj H
机构信息
Host-Pathogen Interactions and Structural Vaccinology Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Host-Pathogen Interactions and Structural Vaccinology Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
出版信息
Trends Pharmacol Sci. 2024 Dec;45(12):1092-1094. doi: 10.1016/j.tips.2024.10.008. Epub 2024 Nov 6.
The essential interaction between Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) and basigin makes RH5 a prime target for broadly neutralizing antibodies. A recent study by Barrett et al. mapped the RH5 antigenic landscape from RH5.1/AS01 vaccinees and identified a potent public antibody clonotype, advancing malaria vaccine and prophylactic antibody development.
恶性疟原虫网织红细胞结合蛋白同源物5（RH5）与疟原虫结合素之间的关键相互作用使RH5成为广泛中和抗体的主要靶点。巴雷特等人最近的一项研究描绘了RH5.1/AS01疫苗接种者的RH5抗原图谱，并确定了一种有效的公共抗体克隆型，推动了疟疾疫苗和预防性抗体的开发。
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