使用BNT162b2进行超快速推广疫苗接种运动对SARS-CoV-2感染发病率的长期有效性。
Long-term effectiveness of an ultra-rapid rollout vaccination campaign with BNT162b2 on the incidence of SARS-CoV-2 infection.
作者信息
Tschiderer Lena, Innerhofer Hanna, Seekircher Lisa, Waltle Lisa, Richter Lukas, Kimpel Janine, Lass-Flörl Cornelia, Forer Lukas, Schönherr Sebastian, Larsen David A, Krammer Florian, Embacher-Aichhorn Sabine, Tilg Herbert, Weiss Günter, Allerberger Franz, Willeit Peter
机构信息
Institute of Clinical Epidemiology, Public Health, Health Economics, Medical Statistics and Informatics, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Institute of Infectious Disease Epidemiology, Austrian Agency for Health and Food Safety, 1220 Vienna, Austria.
出版信息
iScience. 2024 Oct 10;27(11):111117. doi: 10.1016/j.isci.2024.111117. eCollection 2024 Nov 15.
In 2021, an ultra-rapid rollout vaccination campaign in the Schwaz district, Tyrol, Austria, delivered the COVID-19 vaccine BNT162b2 to 66.9% of eligible residents (dose 1: March 11-16, dose 2: April 8-13). Alongside the campaign, we recruited 11,955 residents into the prospective study REDUCE, of whom 3,859 participated in a booster vaccination initiative (November 20-28, 2021). Over a 24-month follow-up, 1,672 participants had incident RT-PCR-confirmed SARS-CoV-2. Compared to other Tyrolean districts, effectiveness in reducing SARS-CoV-2 infection at months 1-9 versus months 10-24 was 81.6% (95% CI 80.0-83.2%; hazard ratio 0.18 [0.17-0.20]) versus 38.2% (35.8-40.6%; 0.62 [0.59-0.64]) among REDUCE participants, and 22.5% (20.5-24.4%; 0.78 [0.76-0.80]) versus 17.0% (16.2-17.8%; 0.83 [0.82-0.84]) in the entire Schwaz district, with substantial variability during follow-up. By March 2023, 61% of Schwaz residents had received booster vaccination versus 55% in other Tyrolean districts. Consequently, vaccinating individuals at high pace effectively reduced SARS-CoV-2 infections and achieved higher vaccination coverage.
2021年，奥地利蒂罗尔州施瓦茨区开展了一场超快速的疫苗接种运动，为66.9%的 eligible residents（第一剂：3月11日至16日，第二剂：4月8日至13日）接种了新冠疫苗BNT162b2。在这场运动期间，我们招募了11955名居民参与前瞻性研究REDUCE，其中3859人参与了加强疫苗接种计划（2021年11月20日至28日）。在24个月的随访中，1672名参与者经逆转录聚合酶链反应（RT-PCR）确诊感染了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。与蒂罗尔州的其他地区相比，在REDUCE参与者中，第1至9个月与第10至24个月相比，减少SARS-CoV-2感染的有效性分别为81.6%（95%置信区间80.0 - 83.2%；风险比0.18 [0.17 - 0.20]）和38.2%（35.8 - 40.6%；0.62 [0.59 - 0.64]），在整个施瓦茨区分别为22.5%（20.5 - 24.4%；0.78 [0.76 - 0.80]）和17.0%（16.2 - 17.8%；0.83 [0.82 - 0.84]），随访期间存在很大差异。到2023年3月，施瓦茨区61%的居民接种了加强疫苗，而蒂罗尔州其他地区这一比例为55%。因此，快速为个人接种疫苗有效地减少了SARS-CoV-2感染，并实现了更高的疫苗接种覆盖率。
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