通过光氧化还原催化的双脱氰化过程实现异腈与（杂）芳烃的Csp-Csp偶联
Csp-Csp Coupling of Isonitriles and (Hetero)arenes through a Photoredox-Catalyzed Double Decyanation Process.
作者信息
Martín María, Romero Rafael Martín, Portolani Chiara, Tortosa Mariola
机构信息
Organic Chemistry Department and Center for Innovation in Advanced Chemistry (ORFEO-CINQA), Universidad Autónoma de Madrid (UAM), 28049 Madrid, Spain.
Department of Industrial Chemistry "Toso Montanari", Alma Mater Studiorum-University of Bologna, via P. Gobetti 85, 40129 Bologna, Italy.
出版信息
ACS Catal. 2024 Nov 8;14(23):17286-17292. doi: 10.1021/acscatal.4c06269. eCollection 2024 Dec 6.
Herein, we demonstrate the ability of isonitriles to be used as alkyl radical precursors in a photoredox-catalyzed transformation involving selective C-N cleavage and Csp-Csp bond formation. This protocol allows for the preparation of functionalized heteroarenes from readily available isonitriles through a decyanation process. The reaction is general for primary, secondary, and tertiary substrates, including amino acid derivatives and druglike molecules.
在此，我们展示了异腈在光氧化还原催化转化中用作烷基自由基前体的能力，该转化涉及选择性C-N裂解和Csp-Csp键形成。该方案允许通过脱氰化过程从容易获得的异腈制备功能化杂芳烃。该反应适用于伯、仲和叔底物，包括氨基酸衍生物和类药物分子。
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