Distribution and antifungal susceptibility of species causing vulvovaginal candidiasis and urinary tract infection in Medlatec healthcare system, Ha Noi city, Vietnam in 2023.

BACKGROUND

Vulvovaginal candidiasis and urinary tract infections caused by are common diseases. While the most common causative agent is , other species, such as non-, can also be responsible. Susceptibility to antifungal drugs varies among species, but there is very limited information available from Vietnam.

OBJECTIVES

To determine the species distribution and antifungal susceptibility patterns of isolated from urine and vaginal samples of patients tested at the Medlatec healthcare system in 2023.

DESIGN

Cross-sectional study.

METHODS

The study describes a cross-sectional analysis of over 102 isolates obtained from urine and vaginal samples of patients using the testing services at Vietnam Medlatec healthcare system from January to December 2023. Species identification of isolates was performed using germ tube test and Vitek 2 systems. Antifungal susceptibility testing was carried out using the VITEK 2 card for yeast fungi. Minimum inhibitory concentrations for these isolates were classified according to the Clinical and Laboratory Standards Institute guidelines (M27-A3 and M27M44S-ED3).

RESULTS

In this investigation, five different species were identified. Among these isolates, (78.43%) was the most frequent, followed by (11.76%), (4.91%), (1.96%), and (0.98%). The resistance rates to fluconazole, voriconazole, caspofungin, micafungin, and amphotericin B were 7.7%, 4.2%, 4.0%, 1.0% and 1.0%, respectively.

CONCLUSION

The most common species found in this population was . Our findings also showed a high frequency of non- species causing fungal urinary tract infections. The resistance rates of isolated strains to echinocandins and amphotericin B were low, while some strains were found to be resistant to fluconazole and voriconazole.