Identification and pattern of antifungal susceptibility of species isolated from cases of vaginitis in a tertiary care hospital in India.

BACKGROUND AND OBJECTIVES

Vulvovaginal candidiasis (VVC) is one of the most frequent reasons for gynecological consultations. is responsible in the majority of cases. Lately, VVC caused by non-albicans spp. (NAC), which are resistant to routinely used antifungals, is on the rise. This study was designed to determine the prevalence of in patients suffering from vaginitis and to assess the predisposing factors along with identification of species and evaluation of their susceptibility profile.

MATERIALS AND METHODS

High vaginal swabs were collected from 225 women. Sample processing consisted of Gram stain and culture onto Sabouraud's dextrose agar and HiChrom Differential agar. Isolates were identified and speciated using VITEK2 Compact System. Susceptibility testing was done using VITEK2 AST-Y S08 cards and disc diffusion.

RESULTS

spp. were isolated from 94 (41.8%) of the cases. was the predominant species (71.6%) followed by other NAC spp. (28.4%). Pregnancy and diabetes were the most frequently implicated risk factors (67.1% and 44.4%). High resistance was observed in NAC spp. as opposed to to all antifungal agents tested.

CONCLUSION

Empirical therapy with routinely used antifungals can be initiated for . In the case of NAC spp., identification should be followed by susceptibility testing.