肿瘤相关巨噬细胞在宫颈癌中的作用及研究进展
The role and research progress of tumor-associated macrophages in cervical cancer.
作者信息
Wang Dan, Han Xue, Liu Hui-Ling
机构信息
Department of First Clinical Medical College, Gansu University of Chinese Medicine Lanzhou, Gansu, China.
Department of Gynecology, Gansu Provincial People's Hospital Lanzhou, Gansu, China.
出版信息
Am J Cancer Res. 2024 Dec 25;14(12):5999-6011. doi: 10.62347/FFXL7288. eCollection 2024.
Tumor-associated macrophages (TAMs) are important immune cells in the tumor micro-environment (TME) and play a key role in the occurrence and development of cervical cancer. Besides, targeting TAMs can significantly inhibit cervical cancer tumor growth, invasion, metastasis, and angiogenesis as well as affect immune regulation. This review summarizes the correlation between TAM and tumors, the mechanism of action of TAM in cervical cancer, and the potential application of TAM in the treatment of cervical cancer. Therefore, this study may provide new ideas and targets for the development of further treatment strategies for cervical cancer patients.
肿瘤相关巨噬细胞（TAMs）是肿瘤微环境（TME）中的重要免疫细胞，在宫颈癌的发生发展中起关键作用。此外，靶向TAMs可显著抑制宫颈癌肿瘤的生长、侵袭、转移和血管生成，并影响免疫调节。本综述总结了TAM与肿瘤之间的相关性、TAM在宫颈癌中的作用机制以及TAM在宫颈癌治疗中的潜在应用。因此，本研究可能为宫颈癌患者进一步治疗策略的开发提供新的思路和靶点。
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