球芽甘蓝可能通过促进乳酸氧化来提高力竭性有氧运动表现及运动后恢复能力：一项随机、单盲、安慰剂对照、双向交叉的初步研究。

Brussels Chicory Enhances Exhaustive Aerobic Exercise Performance and Post-Exercise Recovery, Possibly Through Promotion of Lactate Oxidation: A Pilot Randomized, Single-Blind, Placebo-Controlled, Two-Way Crossover Study.

作者信息

Mao Yihui, Huang Junhao, Li Shuangshuang, Chen Guanyu, Du Yushi, Kang Mengxi, Zhu Shasha, Zhang Wenyu, Xu Qiuhui, Wang Yihan, Ling Wenhua, Luo Xijuan, Wang Dongliang

机构信息

Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road II, Guangzhou 510080, China.

Guangdong Provincial Key Laboratory of Sports and Health Promotion, Scientific Research Center, Guangzhou Sport University, Guangzhou 510500, China.

出版信息

Nutrients. 2025 Jan 20;17(2):365. doi: 10.3390/nu17020365.

DOI:10.3390/nu17020365

PMID:39861495

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11769108/

Abstract

BACKGROUND

Brussels chicory affluent in phenolic acids could inhibit atherosclerosis; however, its effects on exercise performance and post-exercise recovery are unknown. We hypothesized that Brussels chicory could enhance exhaustive aerobic exercise performance and post-exercise recovery by promoting lactate oxidation.

METHODS

This is a single-blind, randomized, placebo-controlled two-way cross-over trial involving 32 untrained college students (men 18) who consumed either Brussels chicory juice (100 g of Brussels chicory containing ~130 mg phenolic acids and 180 mL fresh milk) or placebo (180 mL fresh milk) for 7 days with a 2-week washout period. On the 7th day, participants received a short-term, progressive workload, high-intensity, exhaustive aerobic exercise with the Bruce protocol. Time to exhaustion and blood lactate were evaluated after exercise. C2C12 myotubes were treated with Brussels chicory phenolic acids (0.625-10 μM) to evaluate these effects on lactate metabolism and lactate dehydrogenase A (LDHA) and B (LDHB), two enzymes responsible for lactate biosynthesis and oxidation, respectively.

RESULTS

Brussels chicory consumption increased time to exhaustion by 8.3% and 12.2% for men and women participants, respectively. This administration also promoted post-exercise recovery, evidenced by a reduction in blood lactate (14.5% for men and 10.6% for women). In C2C12 myotubes, Brussels chicory protocatechuic acid and caffeic acid did not affect LHDA-mediated lactate production, whereas these compounds dose-dependently promoted LDHB-mediated lactate oxidation through an enrichment of mitochondria LDHB.

CONCLUSIONS

Dietary supplementation with Brussels chicory may enhance short-term, progressive workload, high-intensity, exhaustive aerobic exercise performance and post-exercise recovery in humans, possibly by accelerating LDHB-mediated lactate oxidation.

摘要

背景

富含酚酸的布鲁塞尔芽球菊苣可抑制动脉粥样硬化；然而，其对运动表现和运动后恢复的影响尚不清楚。我们推测，布鲁塞尔芽球菊苣可通过促进乳酸氧化来提高力竭性有氧运动表现和运动后恢复能力。

方法

这是一项单盲、随机、安慰剂对照的双向交叉试验，纳入32名未经训练的大学生（18名男性），他们饮用布鲁塞尔芽球菊苣汁（100克布鲁塞尔芽球菊苣，含约130毫克酚酸和180毫升鲜牛奶）或安慰剂（180毫升鲜牛奶）7天，洗脱期为2周。在第7天，参与者按照布鲁斯方案进行短期、渐进性负荷、高强度、力竭性有氧运动。运动后评估力竭时间和血乳酸水平。用布鲁塞尔芽球菊苣酚酸（0.625 - 10 μM）处理C2C12肌管，以评估其对乳酸代谢以及分别负责乳酸生物合成和氧化的两种酶——乳酸脱氢酶A（LDHA）和B（LDHB）的影响。

结果

饮用布鲁塞尔芽球菊苣汁使男性和女性参与者的力竭时间分别增加了8.3%和12.2%。这种摄入方式还促进了运动后恢复，表现为血乳酸水平降低（男性降低14.5%，女性降低10.6%）。在C2C12肌管中，布鲁塞尔芽球菊苣的原儿茶酸和咖啡酸不影响LHDA介导的乳酸生成，而这些化合物通过富集线粒体LDHB剂量依赖性地促进LDHB介导的乳酸氧化。