Emerging therapeutic applications of scorpion venom peptides in the Middle East and North Africa: A comprehensive review.

The predominantly arid and semi-arid climate, with high temperatures and vast desert areas in the Middle East and North Africa (MENA) region, creates a favorable environment for scorpions, resulting in diversity of species of different genera. Animal venom, particularly scorpion venom, poses a health risk to victims who are envenomed. However, its abundance of bioactive protein molecules also makes it a promising source for new drug development. Numerous studies worldwide have revealed that venom-based molecules exhibit diverse therapeutic activities, including anticancer, antidiabetic, antimicrobial, anti-hypertensive, immunomodulatory, and analgesic properties. Researchers from MENA region are also actively contributing to this global challenge. In this review, we will explore the abundance and diversity of scorpions in the MENA region and examine recent studies on the therapeutic activities of molecules extracted from their venom. Nonetheless, additional research is needed to address the challenges of developing effective natural drugs from scorpion venom.