Integrating of Radiomics and Single-cell Transcriptomics Uncovers the Crucial Role of γδ T Cells in Lung Adenocarcinoma.

Gamma-delta (γδ) T cells are a crucial component of the tumor immune microenvironment which are considered a promising potential therapeutic strategy and target. Increasing evidence suggests that these unique immune cells play significant roles across various cancers. However, γδ T cells are often regarded as having dual roles in tumors, and their influence on lung adenocarcinoma (LUAD) remains controversial. In this research, we employed a wild-ranging approach using multi-omics data to investigate the function of γδ T cells in LUAD. The abundance of γδ T cell infiltration is linked to a positive prognosis in lung adenocarcinoma. The tumor-inhibiting role of γδ T cells was played through intrinsic lineage evolution, acquiring cytotoxic functions and engaging in signal transduction with antigen-presenting cells. Furthermore, patients with higher γδ T cells infiltration abundance might be more favorable for immunotherapy. Lastly, we established a predictive model using CT images based on radiomics, providing a non-invasive strategy to assess γδ T cells infiltration in LUAD patients. These findings offer new insights and perspectives the personalized therapies of γδ T cells.