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特立帕肽在一名年轻患者中用于治疗椎体爆裂骨折的超说明书用药:病例报告及文献综述

Off-label use of teriparatide for the treatment of a vertebral burst fracture in a young patient: A case report and literature review.

作者信息

Villa Tiziano, Zottola Vincenzo, Mariani Carlo, Borgonovo Alberto, Redenti Luciano

机构信息

G. B. Mangioni Hospital GVM, Lecco, Italy.

Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

出版信息

Trauma Case Rep. 2025 Jan 4;55:101127. doi: 10.1016/j.tcr.2025.101127. eCollection 2025 Feb.

Abstract

We describe a case of L2 vertebral burst fracture in a 40-year-old male patient without any other comorbidities due to a ground-fall from horse. Despite surgical intervention with L1-L3 spine fusion was indicated as the treatment of choice since no fracture healing was visible on CT after 40 days post trauma, a conservative off-label therapy was decided with 5-month administration of teriparatide and vitamin D‑calcium supplementation together with nocturnal pulsed electro-magnetic field. Complete fracture healing was obtained after 5 months. This is the first report of successful off-label use of teriparatide together with pulsed electro-magnetic field for the treatment of a burst vertebral fracture without surgical intervention in a young patient.

摘要

我们描述了一例40岁男性患者,因从马背上摔倒导致L2椎体爆裂骨折,无其他合并症。尽管创伤后40天CT显示无骨折愈合迹象,手术干预首选L1-L3脊柱融合术,但还是决定采用非标签保守治疗,给予5个月的特立帕肽、维生素D-钙补充剂以及夜间脉冲电磁场治疗。5个月后骨折完全愈合。这是首例关于在年轻患者中成功使用特立帕肽联合脉冲电磁场进行非标签治疗爆裂性椎体骨折且无需手术干预的报道。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0c/11782881/776c7f271f4a/gr1.jpg

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