癌症转移中的力学特征。
Mechanical signatures in cancer metastasis.
作者信息
Agrawal Ayushi, Javanmardi Yousef, Watson Sara A, Serwinski Bianca, Djordjevic Boris, Li Wenbin, Aref Amir R, Jenkins Russell W, Moeendarbary Emad
机构信息
Department of Mechanical Engineering, University College London, London, UK.
Division of Biosciences, University College London, London, UK.
出版信息
NPJ Biol Phys Mech. 2025;2(1):3. doi: 10.1038/s44341-024-00007-x. Epub 2025 Feb 4.
The cancer metastatic cascade includes a series of mechanical barrier-crossing events, involving the physical movement of cancer cells from their primary location to a distant organ. This review describes the physical changes that influence tumour proliferation, progression, and metastasis. We identify potential mechanical signatures at every step of the metastatic cascade and discuss some latest mechanobiology-based therapeutic interventions to highlight the importance of interdisciplinary approaches in cancer diagnosis and treatment.
癌症转移级联包括一系列跨越机械屏障的事件，涉及癌细胞从其原发部位向远处器官的物理移动。本综述描述了影响肿瘤增殖、进展和转移的物理变化。我们在转移级联的每一步确定潜在的机械特征，并讨论一些最新的基于力学生物学的治疗干预措施，以强调跨学科方法在癌症诊断和治疗中的重要性。
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