肌萎缩侧索硬化症患者在十年间言语和吞咽功能是否会衰退？
Is there a decline in speech and swallowing in Amyotrophic Lateral Sclerosis over ten years?
作者信息
Mendes Regiani Alabarces, Lima Ivonaldo Leidson Barbosa, Dourado Júnior Mário Emílio Teixeira, Gonçalves Maria de Jesus
机构信息
Departamento de Fonoaudiologia, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte - UFRN - Natal (RN), Brasil.
Departamento de Medicina Integrada, Universidade Federal do Rio Grande do Norte - UFRN - Natal (RN), Brasil.
出版信息
Codas. 2025 Feb 10;37(2):e20240159. doi: 10.1590/2317-1782/e20240159pt. eCollection 2025.
PURPOSE
To analyze the evolution of speech and swallowing decline in patients with amyotrophic lateral sclerosis (ALS) over a ten-year period.
METHODS
A retrospective and longitudinal cohort study. Data were collected using the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) from 101 medical records of ALS patients treated at the multidisciplinary neuromuscular diseases clinic of a University Hospital over a ten-year period. The data were statistically analyzed, adopting a significance level of p<0.05.
RESULTS
The analysis of the studied functions indicated that speech, swallowing, and salivation are altered over ten years in ALS. There are differences in patterns between the variables sex and disease type concerning symptoms related to dysarthria and dysphagia in these individuals, which may indicate the rate of progression over a given time interval.
CONCLUSION
There is a decline in speech and swallowing over ten years in ALS. The bulbar type leads to a faster decline in the studied functions than the spinal type.
目的
分析肌萎缩侧索硬化症（ALS）患者在十年期间言语和吞咽功能衰退的演变情况。
方法
一项回顾性纵向队列研究。使用修订的肌萎缩侧索硬化症功能评定量表（ALSFRS-R），从一家大学医院多学科神经肌肉疾病诊所十年间治疗的101例ALS患者的病历中收集数据。采用p<0.05的显著性水平对数据进行统计分析。
结果
对所研究功能的分析表明，ALS患者在十年间言语、吞咽和唾液分泌功能均发生改变。在这些个体中，性别和疾病类型变量在与构音障碍和吞咽困难相关症状方面存在模式差异，这可能表明在给定时间间隔内的进展速度。
结论
ALS患者在十年间言语和吞咽功能出现衰退。延髓型导致所研究功能的衰退速度比脊髓型更快。
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