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肠道微生物的健康影响与治疗潜力

Health Effects and Therapeutic Potential of the Gut Microbe .

作者信息

Aja Ezinne, Zeng Amber, Gray Weston, Connelley Kaden, Chaganti Anil, Jacobs Jonathan P

机构信息

Goodman-Luskin Microbiome Center, University of California, Los Angeles, CA 90095, USA.

UCLA Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095, USA.

出版信息

Nutrients. 2025 Jan 31;17(3):562. doi: 10.3390/nu17030562.

Abstract

is a bacterium commonly found in the human gastrointestinal tract that has received considerable interest as a potential probiotic for the improvement of gut health and overall metabolic function. is enriched in the mucus layer of the intestinal lining, where it degrades mucin and plays a significant role in gut barrier maintenance and immune regulation. A higher abundance of has been observed in the gut of healthy individuals relative to those with metabolic disorders, and multiple metabolic benefits, including improved glucose management, reduced body fat, and reduced inflammation have been linked to . Current research on primarily relies on mouse models, with limited human interventional studies available. While these animal studies offer valuable insights into the potential roles of in health and disease, further clinical investigations in humans are needed to fully understand its impact. Here, we explore the current scope of research and its potential as a therapeutic agent to improve gut and metabolic health while also emphasizing the need to optimize techniques to further improve studies of this organism.

摘要

是一种常见于人类胃肠道的细菌,作为一种潜在的益生菌,它在改善肠道健康和整体代谢功能方面受到了广泛关注。它在肠黏膜的黏液层中富集,在那里它降解黏蛋白,并在维持肠道屏障和免疫调节中发挥重要作用。相对于患有代谢紊乱的个体,在健康个体的肠道中观察到更高丰度的该细菌,并且多种代谢益处,包括改善血糖管理、减少体脂和减轻炎症,都与该细菌有关。目前对该细菌的研究主要依赖于小鼠模型,可用的人体干预研究有限。虽然这些动物研究为该细菌在健康和疾病中的潜在作用提供了有价值的见解,但仍需要在人体中进行进一步的临床研究,以充分了解其影响。在这里,我们探讨了该细菌研究的当前范围及其作为改善肠道和代谢健康的治疗剂的潜力,同时也强调了优化技术以进一步改进对这种生物体的研究的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db88/11820462/1d955bdcf579/nutrients-17-00562-g001.jpg

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