关于自噬与内皮细胞一氧化氮生成的最新见解
Recent Insights Concerning Autophagy and Endothelial Cell Nitric Oxide Generation.
作者信息
Park Seul-Ki, Cho Jae Min, Mookherjee Sohom, Pires Paulo W, Symons J David
机构信息
Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles.
出版信息
Curr Opin Physiol. 2022 Dec;30. doi: 10.1016/j.cophys.2022.100614. Epub 2022 Nov 4.
Although endothelial cell (EC) dysfunction contributes to the etiology of more diseases than any other tissue in the body, EC metabolism is an understudied therapeutic target. Evidence regarding the important role of autophagy in maintaining EC homeostasis is accumulating rapidly. Here we focus on advances over the past two years regarding how EC autophagy mediates EC nitric oxide generation in the context of aging and cardiovascular complications including coronary artery disease, aneurysm, and stroke. In addition, insight concerning the efficacy of maneuvers designed to boost EC autophagy in an effort to combat cardiovascular complications associated with repressed EC autophagy is discussed.
尽管内皮细胞（EC）功能障碍在更多疾病的病因中所起的作用超过了体内任何其他组织，但内皮细胞代谢仍是一个研究不足的治疗靶点。关于自噬在维持内皮细胞内稳态中的重要作用的证据正在迅速积累。在这里，我们重点关注过去两年中关于内皮细胞自噬在衰老和心血管并发症（包括冠状动脉疾病、动脉瘤和中风）背景下如何介导内皮细胞一氧化氮生成的进展。此外，还讨论了旨在增强内皮细胞自噬以对抗与内皮细胞自噬受抑制相关的心血管并发症的策略的有效性。
Zotero 插件