葡萄糖代谢酶和代谢产物在癌症中的兼职功能。
Moonlighting functions of glucose metabolic enzymes and metabolites in cancer.
作者信息
Guo Dong, Meng Ying, Zhao Gaoxiang, Wu Qingang, Lu Zhimin
机构信息
Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Institute of Fundamental and Transdisciplinary Research, Cancer Center, Zhejiang University, Hangzhou, China.
出版信息
Nat Rev Cancer. 2025 Apr 2. doi: 10.1038/s41568-025-00800-3.
Glucose metabolic enzymes and their metabolites not only provide energy and building blocks for synthesizing macromolecules but also possess non-canonical or moonlighting functions in response to extracellular and intracellular signalling. These moonlighting functions modulate various cellular activities, including gene expression, cell cycle progression, DNA repair, autophagy, senescence and apoptosis, cell proliferation, remodelling of the tumour microenvironment and immune responses. These functions integrate glucose metabolism with other essential cellular activities, driving cancer progression. Targeting these moonlighting functions could open new therapeutic avenues and lead to cancer-specific treatments.
葡萄糖代谢酶及其代谢产物不仅为合成大分子提供能量和构建模块，还在响应细胞外和细胞内信号时具有非经典或兼职功能。这些兼职功能调节各种细胞活动，包括基因表达、细胞周期进程、DNA修复、自噬、衰老和凋亡、细胞增殖、肿瘤微环境重塑和免疫反应。这些功能将葡萄糖代谢与其他基本细胞活动整合在一起，推动癌症进展。针对这些兼职功能可能开辟新的治疗途径，并带来针对癌症的特异性治疗方法。
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