Adjei Timothy Kwabena, Adarkwa Opei Kwafo, Ansu-Yeboah Evans, Ofori Esmond, Arhin Bernard, Tawiah Augustine, Senaya Charles Mawunyo, Tabi Seth Amponsah, Peprah Amponsah, Dassah Edward Tieru, Bempah Atta Owusu
Department of Obstetrics and Gynecology, School of Medicine and Dentistry, College of Health Sciences, Kwame Nkrumah University of Science Technology, Kumasi, Ghana.
Directorate of Obstetrics and Gynecology, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Front Reprod Health. 2025 Apr 3;7:1509737. doi: 10.3389/frph.2025.1509737. eCollection 2025.
Maternal and perinatal morbidities are alarming in Sub-Saharan Africa. However, most of these can be prevented through appropriate care and interventions including preconception care (PCC). There is paucity of data on the effect of PCC on pregnancy outcomes in Ghana. This study sought to determine the association between PCC utilization and late pregnancy outcomes among postpartum women at Komfo Anokye Teaching Hospital (KATH). The study also assessed factors associated with its utilization.
A total of 336 postpartum women from an unmatched 1:2 case-control study, were interviewed. Women with late adverse pregnancy outcomes (APO) in the index pregnancy constituted the case group while those with no APO made up the control group. For every case who gave consent, two consecutive controls were recruited until the sample size was attained. Categorical variables were compared using Chi-square (2) or Fisher's exact test as appropriate, while continuous variables were compared using student t-tests. Multivariable logistic regression analysis was performed to estimate the odds ratios and the association between PCC utilization and pregnancy outcomes as well as factors associated with PCC utilization.
A total of 112 cases and 224 controls were analyzed with comparable mean ages (Cases-30.2 ± 5.97 vrs Controls-30.5 ± 5.89 years, = 0.45). PCC utilization rates were significantly lower among women who suffered late APO (14.3%) than those who did not (25.0%) = 0.0241. PCC utilization was protective of late APO (OR-0.582) but not statistically significant (95% CI, 0.256-1.324; = 0.197). Factors associated with PCC uptake included pregnancy intention (OR- 22.781; 95% CI, 7.883-65.837; = 0.001), knowledge of PCC (OR- 56.4; 95% CI, 16.105-197.517; = 0.001) and pre-existing medical condition (OR-3.976; 95% CI, 1.009-15.677, = 0.049).
PCC utilization rates are low among postpartum women. Women who utilized PCC were twice less likely to suffer any late APO outcome compared to those who did not, though this was not statistically significant. Knowledge of PCC, pregnancy intention, and the presence of pre-existing medical conditions are factors associated with PCC utilization. These findings underscore the need for enhanced PCC education and targeted interventions to improve its utilization, particularly among women at high risk of APO.
撒哈拉以南非洲地区的孕产妇和围产期发病率令人担忧。然而,其中大多数情况可通过适当的护理和干预措施预防,包括孕前保健(PCC)。加纳关于PCC对妊娠结局影响的数据匮乏。本研究旨在确定科姆福·阿诺克耶教学医院(KATH)产后妇女中PCC的使用与晚期妊娠结局之间的关联。该研究还评估了与其使用相关的因素。
对一项非匹配的1:2病例对照研究中的336名产后妇女进行了访谈。索引妊娠中出现晚期不良妊娠结局(APO)的妇女构成病例组,而无APO的妇女组成对照组。对于每一位同意参与的病例,招募两名连续的对照,直至达到样本量。分类变量使用卡方检验(2)或费舍尔精确检验进行比较,连续变量使用学生t检验进行比较。进行多变量逻辑回归分析以估计优势比以及PCC使用与妊娠结局之间的关联,以及与PCC使用相关的因素。
共分析了112例病例和224例对照,平均年龄相当(病例组-30.2±5.97岁,对照组-30.5±5.89岁,P = 0.45)。出现晚期APO的妇女中PCC使用率(14.3%)显著低于未出现晚期APO的妇女(25.0%),P = 0.0241。PCC的使用对晚期APO有保护作用(OR-0.582),但无统计学意义(95%CI,0.256 - 1.324;P = 0.197)。与PCC接受相关的因素包括妊娠意愿(OR-22.781;95%CI,7.883 - 65.837;P = 0.001)、对PCC的了解(OR-56.4;95%CI,16.105 - 197.517;P = 0.001)和既往病史(OR-3.976;95%CI,1.009 - 15.677,P = 0.049)。
产后妇女中PCC使用率较低。与未使用PCC的妇女相比,使用PCC的妇女出现任何晚期APO结局的可能性低两倍,尽管这无统计学意义。对PCC的了解、妊娠意愿和既往病史的存在是与PCC使用相关的因素。这些发现强调需要加强PCC教育和针对性干预措施以提高其使用率,特别是在APO高危妇女中。