血清维生素D与急性肾移植功能障碍的关联
[Association of serum vitamin D and acute renal graft dysfunction].
作者信息
Landeros-García Germán Alfonso, Abraham-Mancilla Severo Manuel, Juárez-Sánchez José Oscar, Jiménez-García Omar Alfredo, Hernández-González Martha Alicia
机构信息
Instituto Mexicano del Seguro Social, Centro Médico Nacional del Bajío, Hospital de Especialidades No. 1, Servicio de Nefrología. León, Guanajuato, México.
Instituto Mexicano del Seguro Social, Centro Médico Nacional del Bajío, Hospital de Especialidades No. 1, División de Investigación en Salud. León, Guanajuato, México.
出版信息
Rev Med Inst Mex Seguro Soc. 2025 May 2;63(3):e6448. doi: 10.5281/zenodo.15178453.
BACKGROUND
Chronic kidney disease (CKD) is a clinical entity characterized by definitive or non-reversible deterioration of the kidney's architecture and/or its functional status. Renal transplantation is the treatment of choice for CKD. New pharmacological therapies have been investigated with the aim of reducing the risk of renal graft rejection; an example of this is vitamin D. However, international evidence presents mixed results.
OBJECTIVE
To evaluate the relationship between serum vitamin D levels and the prevalence of acute renal graft dysfunction in renal transplant patients.
MATERIAL AND METHODS
A prospective, observational and comparative study was carried out with a population of patients who underwent renal transplantation. The patients were classified into 2 groups: group 1: patients with acute graft dysfunction, and group 2, those without acute graft dysfunction.
RESULTS
A statistically significant relationship was found between acute renal graft dysfunction and serum vitamin D levels (p = 0.003). All other characteristics did not show a statistically significant relationship with acute renal graft dysfunction.
CONCLUSIONS
Low 25-hydroxyvitamin D levels showed a statistically significant association with acute renal graft dysfunction.
背景
慢性肾脏病（CKD）是一种以肾脏结构和/或功能状态明确或不可逆恶化为特征的临床病症。肾移植是CKD的首选治疗方法。人们已经研究了新的药物疗法，旨在降低肾移植排斥反应的风险；维生素D就是其中一个例子。然而，国际上的证据呈现出混合的结果。
目的
评估肾移植患者血清维生素D水平与急性肾移植功能障碍患病率之间的关系。
材料与方法
对接受肾移植的患者群体进行了一项前瞻性、观察性和对比性研究。患者被分为两组：第1组：有急性移植功能障碍的患者；第2组：无急性移植功能障碍的患者。
结果
发现急性肾移植功能障碍与血清维生素D水平之间存在统计学上的显著关系（p = 0.003）。所有其他特征与急性肾移植功能障碍均未显示出统计学上的显著关系。
结论
25-羟维生素D水平低与急性肾移植功能障碍存在统计学上的显著关联。
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