嗜铬细胞瘤分泌肾上腺素使脂肪升温。
ETS emerges to heat up adipose.
作者信息
Rodeheffer Matthew S
机构信息
Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA; Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, Connecticut 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
出版信息
Genes Dev. 2025 Jul 1;39(13-14):789-791. doi: 10.1101/gad.352966.125.
In this issue of , Xue and colleagues (doi:10.1101/gad.352748.125) identify ETV4 as a transcription factor binding a -12 kb enhancer of UCP1 to promote chromatin accessibility, histone acetylation, and gene expression. This role for ETV4 in thermogenesis expands its known functions in adipogenesis. Importantly, these findings also highlight an emerging, broader role for E26 transformation-specific (ETS) transcription factors in adipose biology.
在本期的《 》中，薛等人（doi:10.1101/gad.352748.125）确定ETV4为一种转录因子，它与UCP1的一个-12 kb增强子结合，以促进染色质可及性、组蛋白乙酰化和基因表达。ETV4在产热中的这一作用扩展了其在脂肪生成中已知的功能。重要的是，这些发现还凸显了E26转化特异性（ETS）转录因子在脂肪生物学中一个新出现的、更广泛的作用。
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