BNIP3三联征：健康肌肉衰老中的线粒体、溶酶体与炎症
THE BNIP3 TRIAD: MITOCHONDRIA, LYSOSOMES AND INFLAMMATION IN HEALTHY MUSCLE AGING.
作者信息
Irazoki Andrea, Zorzano Antonio, Sebastian David
机构信息
Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10-12, Barcelona, 08028 Spain.
Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, 08028 Spain.
出版信息
Autophagy Rep. 2022 Jun 5;1(1):252-255. doi: 10.1080/27694127.2022.2082202. eCollection 2022.
During aging, skeletal muscle undergoes a loss of mass, strength and function, encompassed in the biological process termed sarcopenia. Given demographic aging, it is essential to comprehend the molecular determinants resulting in age-related sarcopenia. Here we studied the role of the mitophagy adaptor BNIP3 in mitochondrial homeostasis and muscle during aging. Our findings reveal that BNIP3 orchestrates mitochondrial and lysosomal function to mitigate muscle inflammation and atrophy during aging.
在衰老过程中，骨骼肌会出现质量、力量和功能的丧失，这一生物学过程被称为肌肉减少症。鉴于人口老龄化，了解导致与年龄相关的肌肉减少症的分子决定因素至关重要。在这里，我们研究了线粒体自噬衔接蛋白BNIP3在衰老过程中线粒体稳态和肌肉中的作用。我们的研究结果表明，BNIP3协调线粒体和溶酶体功能，以减轻衰老过程中的肌肉炎症和萎缩。
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