Xu Guoqiang, Deng Yuqing, Gao Hua, Wang Baojun, Wang Gang, Ma Ji
Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.
Department of Thoracic Surgery, Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Ther Clin Risk Manag. 2025 May 30;21:817-827. doi: 10.2147/TCRM.S523883. eCollection 2025.
Hip fractures in elderly patients represent a significant healthcare challenge, with substantial morbidity and mortality rates. This study investigated the efficacy of continuous fascia iliaca compartment block (CFICB) in perioperative management.
A retrospective analysis was conducted on elderly patients (≥65 years) with intertrochanteric fractures treated between January 2020 and December 2023. Eligible patients were initially divided into CFICB (n=46) and routine analgesia (RA, n=64) groups. Propensity score matching with a caliper width of 0.21 was performed, yielding 40 patients in each group for final analysis. Matching variables included age, gender, BMI, and ASA score. Primary outcomes were Visual Analog Scale pain scores, cognitive function assessed through a two-tier protocol (Montreal Cognitive Assessment [MoCA©] screening followed by confirmatory Mini-Mental State Examination-2 [MMSE-2Ⓡ] for positive screens), and functional recovery evaluated using the Harris Hip Score.
The CFICB group showed significantly lower VAS scores during the early postoperative period (≤ 72h). This was most notable at 24 hours postoperatively (2.43 ± 0.72 vs 3.45 ± 0.87, < 0.001). Postoperative cognitive dysfunction rates were significantly lower in the CFICB group. The differences were evident at 6h (10% vs 30%, = 0.025), 24h (15% vs 35%, P = 0.039), and 72h (5% vs 20%, P = 0.043). Multivariable analysis identified CFICB as an independent protective factor against postoperative cognitive dysfunction (adjusted OR = 0.41, 95% CI: 0.26-0.65, P < 0.001). Harris Hip Scores at one month postoperatively were significantly higher in the CFICB group (78.56 ± 8.12 vs 72.39 ± 7.65, P = 0.008). Complication rates were comparable between groups (22.5% vs 17.5%, = 0.576).
CFICB effectively improves postoperative pain management, reduces cognitive dysfunction incidence, and enhances early functional recovery in elderly patients with intertrochanteric fractures, while maintaining a favorable safety profile.
老年患者髋部骨折是一项重大的医疗挑战,具有较高的发病率和死亡率。本研究探讨了连续髂筋膜间隙阻滞(CFICB)在围手术期管理中的疗效。
对2020年1月至2023年12月期间接受治疗的老年(≥65岁)转子间骨折患者进行回顾性分析。符合条件的患者最初分为CFICB组(n = 46)和常规镇痛(RA,n = 64)组。进行了卡尺宽度为0.21的倾向评分匹配,最终每组有40名患者进行分析。匹配变量包括年龄、性别、BMI和ASA评分。主要结局指标为视觉模拟量表疼痛评分、通过两级方案评估的认知功能(先进行蒙特利尔认知评估[MoCA©]筛查,对筛查阳性者再进行简易精神状态检查表-2[MMSE-2Ⓡ]确认)以及使用Harris髋关节评分评估的功能恢复情况。
CFICB组术后早期(≤72小时)的VAS评分显著更低。这在术后24小时最为明显(2.43±0.72 vs 3.45±0.87,P<0.001)。CFICB组术后认知功能障碍发生率显著更低。在6小时(10% vs 30%,P = 0.025)、24小时(15% vs 35%,P = 0.039)和72小时(5% vs 20%,P = 0.043)时差异明显。多变量分析确定CFICB是预防术后认知功能障碍的独立保护因素(调整后OR = 0.41,95%CI:0.26 - 0.65,P < 0.001)。CFICB组术后1个月的Harris髋关节评分显著更高(78.56±8.12 vs 72.39±7.65,P = 0.008)。两组间并发症发生率相当(22.5% vs 17.5%,P = 0.576)。
CFICB可有效改善老年转子间骨折患者的术后疼痛管理,降低认知功能障碍发生率,并促进早期功能恢复,同时保持良好的安全性。