哥斯达黎加登革热病毒2型的动态变化：全球流行基因型的出现（2024年）
Shifting Dynamics of DENV2 in Costa Rica: Emergence of the Cosmopolitan Genotype (2024).
作者信息
Gonzalez Elizondo Mauricio, Picado Soto Dihala, Cordero Laurent Estela, Duarte Martínez Francisco, Alcantara Luiz Carlos Junior, Fonseca Vagner, Méndez Rico Jairo Andrés, Lourenco Jose, Franco Leticia, Giovanetti Marta, Soto Garita Claudio
机构信息
Instituto Costarricense de Investigación y Enseñanza en Salud y Nutrición - Centro Nacional de Referencia de Virología. Tres Ríos, La Unión, Cartago, Costa Rica, Centroamérica. 30301.
René Rachou Institute, Oswaldo Cruz Foundation, Belo Horizonte, Brazil University; Stellenbosch, South Africa.
出版信息
medRxiv. 2025 May 29:2025.05.28.25328475. doi: 10.1101/2025.05.28.25328475.
Dengue remains a major public health challenge. In Costa Rica, we implemented the first nationwide genomic surveillance to track the emergence of the DENV2 Cosmopolitan genotype. Phylogenetic and eco-epidemiological analyses revealed early detection, climate-linked spread, and spatial heterogeneity. Findings underscore the need for integrated surveillance to guide adaptive responses to emerging arboviral threats.
登革热仍然是一项重大的公共卫生挑战。在哥斯达黎加，我们开展了首次全国性基因组监测，以追踪登革热病毒2型泛在基因型的出现情况。系统发育分析和生态流行病学分析揭示了早期发现、与气候相关的传播以及空间异质性。研究结果强调了进行综合监测以指导对新出现的虫媒病毒威胁做出适应性应对的必要性。
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