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黄芪多糖真的能提高胰腺癌的治疗效果吗?

Can astragalus polysaccharides truly boost the treatment of pancreatic cancer?

作者信息

Li Xiao-Bing

机构信息

Department of Thoracic Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430079, Hubei Province, China.

出版信息

World J Clin Oncol. 2025 May 24;16(5):101406. doi: 10.5306/wjco.v16.i5.101406.

Abstract

The research on astragalus polysaccharides (APS) in pancreatic cancer has garnered increasing interest due to its potential therapeutic benefits. APS, derived from the Astragalus membranaceus plant, exhibits diverse biological activities, including immune modulation and anti-tumor effects. In this study, we presented a retrospective analysis study exploring the potential benefits of combining APS with gemcitabine plus tegafur gimeracil oteracil potassium capsule (S-1) in pancreatic cancer treatment. The finding suggests that APS may enhance treatment efficacy, improve immune function, and reduce adverse reactions, offering a valuable complementary approach to standard chemotherapy. Further research is needed to validate these findings and optimize APS usage in clinical practice. This combination therapy represents a compelling avenue for improving pancreatic cancer management and may ultimately contribute to better patient outcomes.

摘要

由于黄芪多糖(APS)在胰腺癌治疗中具有潜在的治疗益处,对其的研究已引起越来越多的关注。APS源自黄芪植物,具有多种生物学活性,包括免疫调节和抗肿瘤作用。在本研究中,我们进行了一项回顾性分析研究,探讨APS联合吉西他滨加替吉奥胶囊(S-1)在胰腺癌治疗中的潜在益处。研究结果表明,APS可能提高治疗效果、改善免疫功能并减少不良反应,为标准化疗提供了一种有价值的补充方法。需要进一步的研究来验证这些发现,并在临床实践中优化APS的使用。这种联合治疗是改善胰腺癌治疗的一个有吸引力的途径,最终可能有助于提高患者的治疗效果。

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本文引用的文献

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Recent efficacy and long-term survival of polysaccharide combined with gemcitabine and S-1 in pancreatic cancer.
World J Clin Oncol. 2024 Nov 24;15(11):1404-1411. doi: 10.5306/wjco.v15.i11.1404.
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Genetic Deletion of Galectin-3 Inhibits Pancreatic Cancer Progression and Enhances the Efficacy of Immunotherapy.
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