Davison Natalie, Clements Jennifer, Pruteanu Victoria, Enstone Joanne, Lamagni Theresa, Moganeradj Kartyk, Ryan Yan, MairJenkins John, Roulston Kerry, Stoddart Bethan, Kumbang Jharna
East Midlands Health Protection Team, UK Health Security Agency, Nottingham, UK.
Health Protection Team, NHS Lincolnshire Integrated Care Board, Lincoln, UK.
Epidemiol Infect. 2025 Jun 24;153:e81. doi: 10.1017/S0950268825100204.
In March 2024, the East Midlands Health Protection Team was notified of a case of invasive Group A (iGAS) infection in an elderly care home resident. Twenty-two days later, another case in a resident from the same floor of the care home was notified. In accordance with national guidelines, an outbreak was declared, and a multidisciplinary outbreak control team (OCT) was urgently convened. Screening for GAS throat carriage was undertaken for staff and residents, excluding those receiving end-of-life care. All isolates were strain typed and characterised. Infection prevention and control (IPC) visits were undertaken to provide ongoing support. Screening identified five residents and five staff members positive for GAS. Antibiotic prophylaxis was provided to all staff throughout the setting ( = 74) and all residents on the affected floor ( = 35). Three individuals were positive on repeat screening. All staff and residents screened negative after 4 months and the two clinical cases recovered. Eleven of the 12 GAS isolates were identified as 3.93. This outbreak highlighted the importance of rapid screening, possible only through the deployment of a dedicated team, and rescreening post-decolonising treatment, as a means to contain such outbreaks.
2024年3月,东米德兰兹郡卫生防护小组接到通知,一家老年护理院的一名居民感染了侵袭性A组链球菌(iGAS)。22天后,该护理院同一楼层的另一名居民也被通报感染。根据国家指南,宣布爆发疫情,并紧急召集了一个多学科疫情防控小组(OCT)。对工作人员和居民进行了A组链球菌咽携带筛查,但接受临终关怀的人员除外。所有分离株都进行了菌株分型和特征鉴定。进行了感染预防与控制(IPC)走访,以提供持续支持。筛查发现5名居民和5名工作人员的A组链球菌呈阳性。对整个机构的所有工作人员(n = 74)和受影响楼层的所有居民(n = 35)都给予了抗生素预防治疗。有3人在重复筛查时呈阳性。4个月后,所有工作人员和居民的筛查结果均为阴性,两例临床病例康复。12株A组链球菌分离株中有11株被鉴定为emm 3.93。此次疫情凸显了快速筛查的重要性,这只有通过部署专门的团队才有可能实现,同时也凸显了在去定植治疗后进行重新筛查作为控制此类疫情手段的重要性。