骨骼肌中的胰岛素抵抗与运动诱导的胰岛素敏感性：来自个性化磷酸化蛋白质组学的见解
Insulin resistance and exercise-induced insulin sensitization in skeletal muscle: Insights from personalized phosphoproteomics.
作者信息
Masuda Shun, Matsuzaka Takashi
机构信息
Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
出版信息
J Diabetes Investig. 2025 Sep;16(9):1583-1585. doi: 10.1111/jdi.70113. Epub 2025 Jun 24.
Abstract
Insulin resistance in muscle mainly disrupts non-canonical insulin signaling pathways. Exercise-induced MINDY1 S441 phosphorylation improves insulin sensitivity, highlighting its potential role in mediating exercise benefits in metabolic disease.
摘要
肌肉中的胰岛素抵抗主要破坏非经典胰岛素信号通路。运动诱导的MINDY1 S441磷酸化可改善胰岛素敏感性，突出了其在介导运动对代谢性疾病益处中的潜在作用。
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