急性缺血性卒中治疗后中性粒细胞与淋巴细胞比值与白蛋白比值和90天预后的相关性

Correlation Between NLR to Albumin Ratio and 90-day Prognosis After Treatment for Acute Ischemic Stroke.

作者信息

Liu Peian, Ji Lianhong, Gan Jiale, Yang Xinyi, Deng Yongxing, Liao Junqi, Mo Peiyi, Zhu Qing, Jiang Hui, Han Yunfei, Chen Zhaoyao, Li Wenlei, Wu Minghua, Zhu Yuan

机构信息

Department of Neurology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China.

Department of Neurology, Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, China.

出版信息

J Cardiovasc Transl Res. 2025 Jun 24. doi: 10.1007/s12265-025-10643-w.

DOI:10.1007/s12265-025-10643-w

PMID:40553383

Abstract

The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in relation to albumin levels for acute ischemic stroke (AIS) remains unclear. This study examined the correlation between inflammatory markers and nutritional status to predict 90-day outcomes in patients with AIS. A total of 5855 patients with acute cerebral infarction admitted to the Stroke Center at Jiangsu Province Hospital of Chinese Medicine between June 2017 and September 2023 were retrospectively analyzed. The NLR, SIRI, SII, and NLR-ALb were calculated using peripheral venous blood indicators obtained 24 h post-admission. All patients were followed up 90 days after discharge, and their prognosis was evaluated using the modified Rankin Scale (mRS). Logistic regression analysis, receiver operating characteristics, and Kaplan-Meier survival curves were used to explore the association between inflammatory markers and 90-day outcomes in patients with AIS. In conclusion, higher levels of NLR, SIRI, SII, and the NLR-ALB ratio are associated with poor outcomes following AIS.

摘要

中性粒细胞与淋巴细胞比值（NLR）与白蛋白水平对急性缺血性卒中（AIS）的预后意义尚不清楚。本研究探讨炎症标志物与营养状况之间的相关性，以预测AIS患者90天的预后。回顾性分析了2017年6月至2023年9月期间在江苏省中医院卒中中心收治的5855例急性脑梗死患者。使用入院后24小时获得的外周静脉血指标计算NLR、SIRI、SII和NLR-ALb。所有患者出院后随访90天，采用改良Rankin量表（mRS）评估其预后。采用逻辑回归分析、受试者工作特征分析和Kaplan-Meier生存曲线探讨炎症标志物与AIS患者90天预后之间的关联。总之，较高水平的NLR、SIRI、SII和NLR-ALB比值与AIS后的不良预后相关。