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吸烟对肺癌患者的影响。

The impact of smoking on lung cancer patients.

作者信息

Minervini Fabrizio, Lampridis Savvas, Kestenholz Peter, Pardo Esther, Crommelinck Julie, Putora Paul Martin, Schnider Marlène, Petroncini Matteo, Mayer Nora, Bertoglio Pietro

机构信息

Division of Thoracic Surgery, Cantonal Hospital of Lucerne, Lucerne, Switzerland

National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK.

出版信息

Eur Respir Rev. 2025 Jun 25;34(176). doi: 10.1183/16000617.0175-2024. Print 2025 May.

Abstract

Although smoking prevalence has shown a decreasing trend, the total number of smokers remains high due to population growth. Smoking causes several diseases, including lung cancer, COPD, coronary heart disease, stroke and peripheral vascular disease. Most of the adverse effects of smoking are reversible and smoking cessation treatments are a cost-effective and high-impact intervention for reducing the risk of mortality and morbidity from smoking-related illness. Smoking cessation may have a significant impact in patients diagnosed with lung cancer, as continued tobacco use can critically compromise treatment efficacy, increase the risk of recurrence and reduce overall survival. Moreover, the benefits of smoking cessation in lung cancer patients can also improve quality of life. The tremendous health and economic consequences of the smoking epidemic should make tobacco control a top priority for governments worldwide. This review aims to highlight the necessity of incorporating smoking cessation as a standard component of lung cancer treatment protocols to enhance patients' clinical outcomes and quality of life. At the same time, we identified a lack of current evidence regarding the optimal timing of smoking cessation among lung cancer patients, which provides the basis for further investigation.

摘要

尽管吸烟率呈下降趋势,但由于人口增长,吸烟者总数仍然很高。吸烟会引发多种疾病,包括肺癌、慢性阻塞性肺疾病(COPD)、冠心病、中风和外周血管疾病。吸烟的大多数不良影响是可逆的,戒烟治疗是降低吸烟相关疾病死亡率和发病率风险的一种具有成本效益且影响重大的干预措施。戒烟对肺癌患者可能有重大影响,因为持续吸烟会严重损害治疗效果、增加复发风险并缩短总生存期。此外,肺癌患者戒烟的益处还能改善生活质量。吸烟流行带来的巨大健康和经济后果应使烟草控制成为世界各国政府的首要任务。本综述旨在强调将戒烟纳入肺癌治疗方案标准组成部分的必要性,以提高患者的临床结局和生活质量。同时,我们发现目前缺乏关于肺癌患者最佳戒烟时机的证据,这为进一步研究提供了依据。

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