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严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)亚变体XEC:在KP.3.1.1全球流行率下降背景下出现的新挑战

SARS-CoV-2 subvariant XEC: emerging challenges amidst the global decline of KP.3.1.1.

作者信息

Adejumo Seun Adegboyega, Chukwuma Henry, Ekwebene Onyeka Chukwudalu

机构信息

School of Public Health Sciences, University of Waterloo, Waterloo, ON, Canada.

School of Statistics, University of Minnesota, Twin Cities, Minneapolis, MN, USA.

出版信息

BMC Res Notes. 2025 Jul 24;18(1):322. doi: 10.1186/s13104-025-07371-4.

Abstract

The ongoing COVID-19 pandemic has seen the emergence of numerous SARS-CoV-2 variants, each posing distinct public health challenges. The XEC variant, a recombinant Omicron subvariant, has rapidly gained prevalence globally, raising critical questions about its potential implications on health systems and public policy. This paper examines the emergence, spread, and unique characteristics of XEC, especially in the context of the global decline of KP.3.1.1, another significant Omicron lineage. We discussed the public health implications, including vaccine effectiveness, genomic surveillance, and healthcare system preparedness, underscoring the need for adaptive strategies in response to evolving SARS-CoV-2 variants.

摘要

在持续的新冠疫情中,出现了众多严重急性呼吸综合征冠状病毒2(SARS-CoV-2)变种,每个变种都带来了独特的公共卫生挑战。XEC变种是一种重组奥密克戎亚变种,已在全球迅速流行,引发了关于其对卫生系统和公共政策潜在影响的关键问题。本文研究了XEC的出现、传播及其独特特征,特别是在另一个重要的奥密克戎谱系KP.3.1.1在全球范围内下降的背景下。我们讨论了其公共卫生影响,包括疫苗有效性、基因组监测和医疗系统准备情况,强调了针对不断演变的SARS-CoV-2变种制定适应性策略的必要性。

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