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韩国特应性皮炎治疗的基于共识的指南(第一部分):基础治疗、局部治疗和传统全身治疗。

Consensus-Based Guidelines for the Treatment of Atopic Dermatitis in Korea (Part I): Basic Therapy, Topical Therapy, and Conventional Systemic Therapy.

作者信息

Ko Hyun-Chang, Woo Yu Ri, Ko Joo Yeon, Kim Hye One, Na Chan Ho, Bae Youin, Seo Young-Joon, Shin Min Kyung, Ahn Jiyoung, Lew Bark-Lynn, Lee Dong Hun, Lee Sang Eun, Lee Sul Hee, Lee Yang Won, Lee Ji Hyun, Jang Yong Hyun, Jeon Jiehyun, Choi Sun Young, Han Ju Hee, Han Tae Young, Son Sang Wook, Cho Sang Hyun

机构信息

Department of Dermatology, Pusan National University School of Medicine, Busan, Korea.

Department of Dermatology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

出版信息

Ann Dermatol. 2025 Aug;37(4):201-215. doi: 10.5021/ad.24.153.

Abstract

BACKGROUND

Atopic dermatitis (AD) is a common skin disease with a wide range of symptoms. Due to the rapidly changing treatment landscape, regular updates to clinical guidelines are needed.

OBJECTIVE

This study aimed to update the guidelines for the treatment of AD to reflect recent therapeutic advances and evidence-based practices.

METHODS

The Patient characteristics, type of Intervention, Control, and Outcome framework was used to determine 48 questions related to AD management. Evidence was graded, recommendations were determined, and, after 2 voting rounds among the Korean Atopic Dermatitis Association (KADA) council members, consensus was achieved.

RESULTS

The guidelines provide detailed recommendations on foundational therapies, including the use of moisturizers, cleansing and bathing practices, allergen avoidance, and patient education. Guidance on topical therapies, such as topical corticosteroids and calcineurin inhibitors, is also provided to help manage inflammation and maintain skin barrier function in patients with AD. Additionally, recommendations on conventional systemic therapies, including corticosteroids, cyclosporine, and methotrexate, are provided for managing moderate to severe AD.

CONCLUSION

KADA's updated AD guidelines offer clinicians evidence-based strategies focused on basic therapies, topical therapies, and conventional systemic therapies, equipping them to enhance quality of care and improve patient outcomes in AD management.

摘要

背景

特应性皮炎(AD)是一种具有广泛症状的常见皮肤病。由于治疗格局迅速变化,临床指南需要定期更新。

目的

本研究旨在更新AD治疗指南,以反映近期的治疗进展和循证实践。

方法

采用患者特征、干预类型、对照和结局框架来确定48个与AD管理相关的问题。对证据进行分级,确定推荐意见,并在韩国特应性皮炎协会(KADA)理事会成员进行两轮投票后达成共识。

结果

该指南提供了关于基础治疗的详细推荐,包括保湿剂的使用、清洁和沐浴方法、避免接触过敏原以及患者教育。还提供了关于局部治疗的指导,如局部用皮质类固醇和钙调神经磷酸酶抑制剂,以帮助控制AD患者的炎症并维持皮肤屏障功能。此外,针对中度至重度AD的管理,提供了关于传统全身治疗的推荐,包括皮质类固醇、环孢素和甲氨蝶呤。

结论

KADA更新的AD指南为临床医生提供了基于证据的策略,重点关注基础治疗、局部治疗和传统全身治疗,使他们能够在AD管理中提高护理质量并改善患者结局。

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