RNA结合蛋白牵拉染色质环。 - Suppr

RNA-binding proteins pull in chromatin loops.

作者信息

Dean Ann

机构信息

Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

出版信息

Nat Cell Biol. 2025 Sep 8. doi: 10.1038/s41556-025-01743-5.

DOI:10.1038/s41556-025-01743-5

PMID:40921735

Abstract

摘要

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本文引用的文献

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Mol Cell. 2024 Apr 4;84(7):1271-1289.e12. doi: 10.1016/j.molcel.2024.01.026. Epub 2024 Feb 21.

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Nat Rev Genet. 2023 Feb;24(2):73-85. doi: 10.1038/s41576-022-00530-4. Epub 2022 Sep 30.

Opposing Effects of Cohesin and Transcription on CTCF Organization Revealed by Super-resolution Imaging.

Mol Cell. 2020 Nov 19;80(4):699-711.e7. doi: 10.1016/j.molcel.2020.10.001. Epub 2020 Oct 21.

Biomolecular Condensates in the Nucleus.

Trends Biochem Sci. 2020 Nov;45(11):961-977. doi: 10.1016/j.tibs.2020.06.007. Epub 2020 Jul 17.

RNA Interactions Are Essential for CTCF-Mediated Genome Organization.

Mol Cell. 2019 Nov 7;76(3):412-422.e5. doi: 10.1016/j.molcel.2019.08.015. Epub 2019 Sep 12.

Distinct Classes of Chromatin Loops Revealed by Deletion of an RNA-Binding Region in CTCF.

Mol Cell. 2019 Nov 7;76(3):395-411.e13. doi: 10.1016/j.molcel.2019.07.039. Epub 2019 Sep 12.

Formation of Chromosomal Domains by Loop Extrusion.

Cell Rep. 2016 May 31;15(9):2038-49. doi: 10.1016/j.celrep.2016.04.085. Epub 2016 May 19.

Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6456-65. doi: 10.1073/pnas.1518552112. Epub 2015 Oct 23.

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相似文献

RNA-binding proteins pull in chromatin loops.

Nat Cell Biol. 2025 Sep 8. doi: 10.1038/s41556-025-01743-5.

RNA Stabilizes Transcription-Dependent Chromatin Loops Induced By Nuclear Hormones.

Sci Rep. 2019 Mar 8;9(1):3925. doi: 10.1038/s41598-019-40123-6.

Chromosome organization by one-sided and two-sided loop extrusion.

Elife. 2020 Apr 6;9:e53558. doi: 10.7554/eLife.53558.

Distinct Classes of Chromatin Loops Revealed by Deletion of an RNA-Binding Region in CTCF.

Mol Cell. 2019 Nov 7;76(3):395-411.e13. doi: 10.1016/j.molcel.2019.07.039. Epub 2019 Sep 12.

Regulation of chromatin structure and cell fate by R-loops.

Transcription. 2016 Aug 7;7(4):121-6. doi: 10.1080/21541264.2016.1198298. Epub 2016 Jun 21.

Back-spliced RNA from retrotransposon binds to centromere and regulates centromeric chromatin loops in maize.

PLoS Biol. 2020 Jan 29;18(1):e3000582. doi: 10.1371/journal.pbio.3000582. eCollection 2020 Jan.

ZNF143 is a regulator of chromatin loop.

Cell Biol Toxicol. 2018 Dec;34(6):471-478. doi: 10.1007/s10565-018-9443-z. Epub 2018 Aug 17.

Building an integrated view of R-loops, transcription, and chromatin.

DNA Repair (Amst). 2025 May;149:103832. doi: 10.1016/j.dnarep.2025.103832. Epub 2025 Apr 8.

A CTCF-Binding Element and Histone Deacetylation Cooperatively Maintain Chromatin Loops, Linking to Long-Range Gene Regulation in Cancer Genomes.

Front Oncol. 2022 Jan 21;11:821495. doi: 10.3389/fonc.2021.821495. eCollection 2021.

Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.

EMBO J. 2017 Dec 15;36(24):3573-3599. doi: 10.15252/embj.201798004. Epub 2017 Dec 7.

本文引用的文献

Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo.

Mol Cell. 2024 Apr 4;84(7):1271-1289.e12. doi: 10.1016/j.molcel.2024.01.026. Epub 2024 Feb 21.

New insights into genome folding by loop extrusion from inducible degron technologies.

Nat Rev Genet. 2023 Feb;24(2):73-85. doi: 10.1038/s41576-022-00530-4. Epub 2022 Sep 30.

Opposing Effects of Cohesin and Transcription on CTCF Organization Revealed by Super-resolution Imaging.

Mol Cell. 2020 Nov 19;80(4):699-711.e7. doi: 10.1016/j.molcel.2020.10.001. Epub 2020 Oct 21.

Biomolecular Condensates in the Nucleus.

Trends Biochem Sci. 2020 Nov;45(11):961-977. doi: 10.1016/j.tibs.2020.06.007. Epub 2020 Jul 17.

RNA Interactions Are Essential for CTCF-Mediated Genome Organization.

Mol Cell. 2019 Nov 7;76(3):412-422.e5. doi: 10.1016/j.molcel.2019.08.015. Epub 2019 Sep 12.

Distinct Classes of Chromatin Loops Revealed by Deletion of an RNA-Binding Region in CTCF.

Mol Cell. 2019 Nov 7;76(3):395-411.e13. doi: 10.1016/j.molcel.2019.07.039. Epub 2019 Sep 12.

Formation of Chromosomal Domains by Loop Extrusion.

Cell Rep. 2016 May 31;15(9):2038-49. doi: 10.1016/j.celrep.2016.04.085. Epub 2016 May 19.

Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6456-65. doi: 10.1073/pnas.1518552112. Epub 2015 Oct 23.

RNA-binding proteins pull in chromatin loops.

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