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按年龄、性别和激素使用情况划分的成年人群中脂蛋白甘油三酯和脂蛋白胆固醇的分布——太平洋西北贝尔电话公司健康调查

Distribution of lipoproteins triglyceride and lipoprotein cholesterol in an adult population by age, sex, and hormone use- The Pacific Northwest Bell Telephone Company health survey.

作者信息

Wahl P W, Warnick G R, Albers J J, Hoover J J, Walden C E, Bergelin R O, Ogilvie J T, Hazzard W R, Knopp R H

出版信息

Atherosclerosis. 1981 Apr;39(1):111-24. doi: 10.1016/0021-9150(81)90093-9.

Abstract

This report describes the distribution of lipoprotein triglyceride and lipoprotein cholesterol in employees of the Pacific Northwest Bell Telephone Company. Means, medians, and selected percentiles are presented for very low, low, and high density lipoproteins (VLDL, LDL, and HDL, respectively) in 606 randomly selected white subjects aged 20-59. Results are specific for age decade, sex, and female sex hormone usage. Women who use sex hormones have significantly higher concentrations of triglycerides in all of the fractions across all age decades from 20 to 59 than do women not taking hormones. The average VLDL, LDL, and HDL triglyceride levels in women taking hormones are 69, 25 and 18 mg/dl which are considerably higher than the corresponding averages of 44, 17 and 12 mg/dl noted in women not taking hormones. Men have the highest average VLDL triglyceride value (85 mg/dl) but their average triglyceride concentrations in the LDL and HDL fractions (18 and 12 mg/dl) approximate those of women not taking hormones. This study in a well-defined population provides references standards for lipoprotein triglyceride concentrations. These results can be used to evaluate the effect of sex hormone treatment on the lipoprotein triglyceride content in VLDL, LDL and HDL, and to assess triglyceride content as a potential risk factor in men and older women.

摘要

本报告描述了太平洋西北贝尔电话公司员工脂蛋白甘油三酯和脂蛋白胆固醇的分布情况。给出了606名年龄在20 - 59岁之间随机选取的白人受试者中极低密度脂蛋白、低密度脂蛋白和高密度脂蛋白(分别为VLDL、LDL和HDL)的均值、中位数和选定百分位数。结果按年龄 decade、性别和女性性激素使用情况进行了具体分析。在20至59岁的所有年龄 decade中,使用性激素的女性在所有组分中的甘油三酯浓度均显著高于未使用激素的女性。使用激素的女性中,VLDL、LDL和HDL甘油三酯的平均水平分别为69、25和18毫克/分升,远高于未使用激素女性相应的平均水平44、17和12毫克/分升。男性的VLDL甘油三酯平均水平最高(85毫克/分升),但其LDL和HDL组分中的甘油三酯平均浓度(18和12毫克/分升)与未使用激素的女性相近。这项在明确界定人群中的研究为脂蛋白甘油三酯浓度提供了参考标准。这些结果可用于评估性激素治疗对VLDL、LDL和HDL中脂蛋白甘油三酯含量的影响,并将甘油三酯含量评估为男性和老年女性的潜在风险因素。

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