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CD-Search：即时蛋白质结构域注释

CD-Search: protein domain annotations on the fly.

作者信息

Marchler-Bauer Aron, Bryant Stephen H

机构信息

Computational Biology Branch, NCBI, National Library of Medicine, NIH, Building 38A, Room 5S508, 8600 Rockville Pike, Bethesda, MD 20894, USA.

出版信息

Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W327-31. doi: 10.1093/nar/gkh454.

DOI:10.1093/nar/gkh454
PMID:15215404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC441592/
Abstract

We describe the Conserved Domain Search service (CD-Search), a web-based tool for the detection of structural and functional domains in protein sequences. CD-Search uses BLAST(R) heuristics to provide a fast, interactive service, and searches a comprehensive collection of domain models. Search results are displayed as domain architecture cartoons and pairwise alignments between the query and domain-model consensus sequences. Search results may be visualized in further detail by embedding the query sequence into multiple alignment displays and by mapping onto three-dimensional molecular graphic displays of known structures within the domain family. CD-Search can be accessed at http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi.

摘要

我们描述了保守结构域搜索服务（CD-Search），这是一种基于网络的工具，用于检测蛋白质序列中的结构和功能结构域。CD-Search使用BLAST(R)启发式算法提供快速、交互式服务，并搜索全面的结构域模型集合。搜索结果以结构域架构卡通图以及查询序列与结构域模型一致序列之间的两两比对形式显示。通过将查询序列嵌入多序列比对显示中，并映射到结构域家族内已知结构的三维分子图形显示上，可以更详细地可视化搜索结果。可通过http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi访问CD-Search。

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