白细胞介素-2与白细胞介素-15的生物学特性：对癌症治疗和疫苗设计的启示

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design.

作者信息

Waldmann Thomas A

机构信息

Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

Nat Rev Immunol. 2006 Aug;6(8):595-601. doi: 10.1038/nri1901.

DOI:10.1038/nri1901

PMID:16868550

Abstract

Interleukin-2 and interleukin-15 have pivotal roles in the control of the life and death of lymphocytes. Although their heterotrimeric receptors have two receptor subunits in common, these two cytokines have contrasting roles in adaptive immune responses. The unique role of interleukin-2 is in the elimination of self-reactive T cells to prevent autoimmunity. By contrast, interleukin-15 is dedicated to the prolonged maintenance of memory T-cell responses to invading pathogens. As discussed in this Review, the biology of these cytokines will affect the development of novel therapies for malignancy and autoimmune diseases, as well as the design of vaccines against infectious diseases.

摘要

白细胞介素-2和白细胞介素-15在淋巴细胞生死调控中起关键作用。尽管它们的异源三聚体受体有两个共同的受体亚基，但这两种细胞因子在适应性免疫反应中发挥着相反的作用。白细胞介素-2的独特作用是消除自身反应性T细胞以预防自身免疫。相比之下，白细胞介素-15致力于对入侵病原体的记忆性T细胞反应的长期维持。正如本综述中所讨论的，这些细胞因子的生物学特性将影响恶性肿瘤和自身免疫性疾病新疗法的开发，以及针对传染病疫苗的设计。