Buabeng Kwame O, Duwiejua Mahama, Dodoo Alex N O, Matowe Lloyd K, Enlund Hannes
Department of Social Pharmacy, University of Kuopio, Finland.
Malar J. 2007 Jul 2;6:85. doi: 10.1186/1475-2875-6-85.
To assess the appropriateness of self-reported use of anti-malarial drugs prior to health facility attendance, and the management of malaria in two health facilities in Ghana.
A structured questionnaire was used to collect data from 500 respondents who were diagnosed clinically and/or parasitologically for malaria at Agogo Presbyterian Hospital and Suntreso Polyclinic, both in the Ashanti Region of Ghana. Collected information included previous use of anti-malarial drugs prior to attending the health facilities, types of drugs used, how the drugs were used, and the sources of the drugs. In addition, the anti-malarial therapy given and outcomes at the two health facilities were assessed.
Of the 500 patients interviewed, 17% had severe malaria, 8% had moderate to severe malaria and 75% had uncomplicated malaria. Forty three percent of the respondents had taken anti-malarial drugs within two weeks prior to hospital attendance. The most commonly used anti-malarials were chloroquine (76%), sulphadoxine-pyrimethamine (9%), herbal preparations (9%) and amodiaquine (6%). The sources of these medicines were licensed chemical sellers (50%), pharmacies (21%), neighbouring clinics (9%) or "other" sources (20%) including left-over medicines at home. One hundred and sixty three (77%) of the 213 patients who had used anti-malarial drugs prior to attending the health facilities, used the drugs inappropriately. At the health facilities, the anti-malarials were prescribed and used according to the national standard treatment guidelines with good outcomes.
Prevalence of inappropriate use of anti-malarials in the community in Ghana is high. There is need for enhanced public health education on home-based management of malaria and training for workers in medicine supply outlets to ensure effective use of anti-malaria drugs in the country.
评估在前往医疗机构就诊前自我报告使用抗疟药物的合理性,以及加纳两家医疗机构对疟疾的管理情况。
采用结构化问卷对500名在加纳阿散蒂地区的阿戈戈长老会医院和孙特雷索综合诊所临床诊断和/或寄生虫学诊断为疟疾的受访者收集数据。收集的信息包括在前往医疗机构就诊前先前使用抗疟药物的情况、使用的药物类型、药物的使用方式以及药物来源。此外,还评估了两家医疗机构给予的抗疟治疗及治疗结果。
在接受访谈的500名患者中,17%患有重症疟疾,8%患有中度至重度疟疾,75%患有非重症疟疾。43%的受访者在前往医院就诊前两周内服用过抗疟药物。最常用的抗疟药物是氯喹(76%)、磺胺多辛-乙胺嘧啶(9%)、草药制剂(9%)和阿莫地喹(6%)。这些药物的来源是有执照的药品销售商(50%)、药店(21%)、邻近诊所(9%)或“其他”来源(20%),包括家中剩余的药物。在前往医疗机构就诊前使用过抗疟药物的213名患者中,有163名(77%)用药不当。在医疗机构,抗疟药物是根据国家标准治疗指南开具和使用的,治疗效果良好。
加纳社区抗疟药物使用不当的患病率很高。需要加强关于疟疾家庭管理的公共卫生教育,并对药品供应点的工作人员进行培训,以确保该国有效使用抗疟药物。