葡萄糖转运体5在外毛细胞中无法检测到，并且对耳蜗放大没有作用。
Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification.
作者信息
Wu Xudong, Wang Xiang, Gao Jiangang, Yu Yiling, Jia Shuping, Zheng Jing, Dallos Peter, He David Z Z, Cheatham MaryAnn, Zuo Jian
机构信息
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
出版信息
Brain Res. 2008 May 19;1210:20-8. doi: 10.1016/j.brainres.2008.02.094. Epub 2008 Mar 18.
Abstract
Glucose transporter 5 (Glut5) is a high-affinity fructose transporter. It was proposed to be a motor protein or part of the motor complex required for cochlear amplification in outer hair cells (OHCs). Here we show that, in contrast to previous reports, Glut5 is undetectable, and possibly absent, in OHCs harvested from wildtype mice. Further, Glut5-deficient mice display normal OHC morphology and motor function (i.e., nonlinear capacitance and electromotility) and normal cochlear sensitivity and frequency selectivity. We conclude that Glut5 is not required for OHC motility or cochlear amplification.
摘要
葡萄糖转运蛋白5（Glut5）是一种高亲和力的果糖转运蛋白。曾有人提出它是外毛细胞（OHC）中耳蜗放大所需的运动蛋白或运动复合体的一部分。在此我们表明，与之前的报道相反，在从野生型小鼠获取的OHC中检测不到Glut5，甚至可能不存在。此外，Glut5基因敲除小鼠表现出正常的OHC形态和运动功能（即非线性电容和电运动）以及正常的耳蜗敏感性和频率选择性。我们得出结论，OHC运动或耳蜗放大不需要Glut5。
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