趋化作用中的方向感知。
Directional sensing during chemotaxis.
作者信息
Janetopoulos Christopher, Firtel Richard A
机构信息
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.
出版信息
FEBS Lett. 2008 Jun 18;582(14):2075-85. doi: 10.1016/j.febslet.2008.04.035. Epub 2008 Apr 29.
Abstract
Cells have the innate ability to sense and move towards a variety of chemoattractants. We investigate the pathways by which cells sense and respond to chemoattractant gradients. We focus on the model system Dictyostelium and compare our understanding of chemotaxis in this system with recent advances made using neutrophils and other mammalian cell types, which share many molecular components and signaling pathways with Dictyostelium. This review also examines models that have been proposed to explain how cells are able to respond to small differences in ligand concentrations between the anterior leading edge and posterior of the cell. In addition, we highlight the overlapping functions of many signaling components in diverse processes beyond chemotaxis, including random cell motility and cell division.
摘要
细胞具有感知并向多种趋化因子移动的内在能力。我们研究细胞感知和响应趋化因子梯度的途径。我们聚焦于盘基网柄菌模型系统，并将我们对该系统中趋化作用的理解与使用中性粒细胞和其他哺乳动物细胞类型所取得的最新进展进行比较，这些细胞类型与盘基网柄菌共享许多分子成分和信号通路。本综述还探讨了为解释细胞如何能够响应细胞前缘和后缘之间配体浓度的微小差异而提出的模型。此外，我们强调了许多信号成分在趋化作用之外的多种过程中的重叠功能，包括随机细胞运动和细胞分裂。
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