衰老及抗衰老干预中的过氧化物酶体增殖物激活受体γ辅激活因子1α（PGC-1α）
PGC-1alpha in aging and anti-aging interventions.
作者信息
Anderson Rozalyn, Prolla Tomas
机构信息
Wisconsin National Primate Research Center, Madison, WI 53715, USA.
出版信息
Biochim Biophys Acta. 2009 Oct;1790(10):1059-66. doi: 10.1016/j.bbagen.2009.04.005. Epub 2009 Apr 14.
Abstract
Deregulation of mitochondrial function is a common feature in multiple aspects of aging. In addition to playing a role in aging-associated disease, decline in mitochondrial energy metabolism is likely to be important in the development of metabolic disease. Furthermore, altered mitochondrial function is a conserved feature in caloric restriction--a dietary intervention that delays aging in diverse species. The transcriptional co-activator PGC-1alpha is a critical regulator of mitochondrial energy metabolism and biogenesis. PGC-1alpha is uniquely poised as a potential target for correcting the effects of age on mitochondrial decline. We describe the cellular and tissue specific mechanisms of PGC-1alpha regulation and illustrate how these pathways may be involved in the aging process.
摘要
线粒体功能失调是衰老多个方面的共同特征。除了在与衰老相关的疾病中起作用外，线粒体能量代谢的下降在代谢性疾病的发展中可能也很重要。此外，线粒体功能改变是热量限制（一种能延缓多种物种衰老的饮食干预措施）中的一个保守特征。转录共激活因子PGC-1α是线粒体能量代谢和生物合成的关键调节因子。PGC-1α作为纠正年龄对线粒体衰退影响的潜在靶点具有独特的优势。我们描述了PGC-1α调节的细胞和组织特异性机制，并阐明了这些途径可能如何参与衰老过程。
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